5ELP

Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2B Superfamily	KASAT domain-like	8055844	3002319	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	Thiolase-like	8055846	3000122	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Thiolase-like	8055846	3000122	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	KASAT domain-like	8055844	3002319	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Thiolase-like	8055846	3000122	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	KASAT domain-like	8055844	3002319	SCOP2B (2022-06-29)
D	SCOP2 Family	Thiolase-related	8055845	4000245	SCOP2 (2022-06-29)
D	SCOP2 Family	KASAT domain-like	8045096	4004293	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Thiolase-like	8055846	3000122	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	KASAT domain-like	8055844	3002319	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF22336	e5elpC3	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PF22336	ECOD (1.6)
A [auth C]	PF00109	e5elpC2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
A [auth C]	PF02801	e5elpC1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
B [auth A]	PF22336	e5elpA3	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PF22336	ECOD (1.6)
B [auth A]	PF00109	e5elpA1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
B [auth A]	PF02801	e5elpA2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
C [auth B]	PF22336	e5elpB3	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PF22336	ECOD (1.6)
C [auth B]	PF00109	e5elpB2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
C [auth B]	PF02801	e5elpB1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
D	PF22336	e5elpD1	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PF22336	ECOD (1.6)
D	PF00109	e5elpD3	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
D	PF02801	e5elpD2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B [auth A]	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C [auth B]	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B], D	PF02801	Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)	Beta-ketoacyl synthase, C-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	Domain
A [auth C], B [auth A], C [auth B], D	PF00109	Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)	Beta-ketoacyl synthase, N-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].	Domain
A [auth C], B [auth A], C [auth B], D	PF16197	Ketoacyl-synthetase C-terminal extension (KAsynt_C_assoc)	Ketoacyl-synthetase C-terminal extension	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B], D	NRPS/PKS protein	vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity	organic substance metabolic process organonitrogen compound metabolic process biosynthetic process organonitrogen compound biosynthetic process organic substance biosynthetic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process organic substance metabolic process organonitrogen compound metabolic process biosynthetic process organonitrogen compound biosynthetic process organic substance biosynthetic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process cellular lipid metabolic process small molecule metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B], D	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A [auth C], B [auth A], C [auth B], D	IPR006162	Phosphopantetheine attachment site	PTM
A [auth C], B [auth A], C [auth B], D	IPR020807	Polyketide synthase, dehydratase domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A [auth C], B [auth A], C [auth B], D	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A [auth C], B [auth A], C [auth B], D	IPR049551	Polyketide synthase, dehydratase domain, C-terminal	Domain
A [auth C], B [auth A], C [auth B], D	IPR020845	AMP-binding, conserved site	Conserved Site
A [auth C], B [auth A], C [auth B], D	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR001242	Condensation domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR036736	ACP-like superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR025110	AMP-binding enzyme, C-terminal domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR032821	Polyketide synthase, C-terminal extension	Domain
A [auth C], B [auth A], C [auth B], D	IPR009081	Phosphopantetheine binding ACP domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR010071	Amino acid adenylation domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR016039	Thiolase-like	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR045851	AMP-binding enzyme, C-terminal domain superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR042099	ANL, N-terminal domain	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B], D	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A [auth C], B [auth A], C [auth B], D	IPR000873	AMP-dependent synthetase/ligase domain	Domain
A [auth C], B [auth A], C [auth B], D	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily

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5ELP

Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42

External Resource: Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage