5EH4

Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01102	e5eh4A1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: PF01102	ECOD (1.6)
B	PF01102	e5eh4B1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: PF01102	ECOD (1.6)
C	PF01102	e5eh4C1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: PF01102	ECOD (1.6)
D	PF01102	e5eh4D1	A: extended segments	X: Glycophorin-A transmembrane domain (From Topology)	H: Glycophorin-A transmembrane domain (From Topology)	T: Glycophorin-A transmembrane domain	F: PF01102	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01102	Glycophorin A (Glycophorin_A)	Glycophorin A	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Glycophorin-A	protein binding binding virus receptor activity exogenous protein binding identical protein binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane ankyrin-1 complex protein-containing complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane ankyrin-1 complex protein-containing complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018938	Glycophorin, conserved site	Conserved Site
A, B, C, D	IPR001195	Glycophorin	Family
A, B, C, D	IPR049535	Glycophorin A/B	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P02724	malaria skin neoplasm skin cancer chronic obstructive pulmonary disease osteosarcoma sarcoidosis MALT lymphoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM				Glycophorin

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	SCH	Parent Component: CYS RESID: AA0101 PSI-MOD : L-cysteine methyl disulfide MOD:00110

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.