5E5R

Crystal structure of the complex between Carbonic anhydrase-like domain of PTPRG and Immunoglobulin domains 2-3 of CNTN3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5e5ra_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5e5rc_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5e5rb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d5e5rd1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbonic anhydrase	8065113	3001672	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carbonic anhydrase	8065113	3001672	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00194	e5e5rA1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: PF00194	ECOD (1.6)
C	PF00194	e5e5rC1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: PF00194	ECOD (1.6)
B	PF13927	e5e5rB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)
D	PF13927	e5e5rD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF13927	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
C	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain
B, D	PF13927	Immunoglobulin domain (Ig_3)	Immunoglobulin domain	This family contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Receptor-type tyrosine-protein phosphatase gamma	phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity identical protein binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity identical protein binding protein binding binding	multicellular organismal process negative regulation of locomotion regulation of cell motility regulation of cellular process negative regulation of biological process tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of multicellular organismal process cell migration epithelial cell migration cell motility multicellular organismal process negative regulation of locomotion regulation of cell motility regulation of cellular process negative regulation of biological process tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process regulation of multicellular organismal process cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration regulation of biological process biological regulation epithelium migration regulation of locomotion negative regulation of cell motility cellular process negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization dephosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane
B, D	Contactin-3	-	developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development cellular process cellular component organization or biogenesis system development cell adhesion	membrane cellular anatomical entity side of membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR041887	Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain	Domain
A, C	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, C	IPR001148	Alpha carbonic anhydrase domain	Domain
A, C	IPR003961	Fibronectin type III	Domain
A, C	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, C	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, C	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A, C	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, C	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, C	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D	IPR003599	Immunoglobulin subtype	Domain
B, D	IPR003598	Immunoglobulin subtype 2	Domain
B, D	IPR003961	Fibronectin type III	Domain
B, D	IPR007110	Immunoglobulin-like domain	Domain
B, D	IPR013098	Immunoglobulin I-set	Domain
B, D	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P23470	myopathy osteosarcoma pilocytic astrocytoma sinusitis adenoma atypical teratoid rhabdoid tumor Crohn disease gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma Malignant neoplasm of stomach non-small cell lung carcinoma ovarian cancer pituitary cancer subependymal giant cell astrocytoma myopathy osteosarcoma pilocytic astrocytoma sinusitis adenoma atypical teratoid rhabdoid tumor Crohn disease gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma Malignant neoplasm of stomach non-small cell lung carcinoma ovarian cancer pituitary cancer subependymal giant cell astrocytoma adrenal cortex carcinoma brain aneurysm cystic fibrosis gastric carcinoma interstitial cystitis lung cancer medulloblastoma oligodendroglioma Pick disease progressive supranuclear palsy ulcerative colitis astrocytic tumor breast cancer ductal breast carcinoma in situ gastric neoplasm invasive ductal breast carcinoma malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.