5E0I

Crystal structure of the HBV capsid Y132A mutant (VCID 8772) in complex with NVR10-001E2 at 1.95A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d5e0ic1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
C	d5e0ic3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
C	d5e0ic2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
F	d5e0if1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
F	d5e0if3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
F	d5e0if2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
A	d5e0ia1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
A	d5e0ia3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
A	d5e0ia2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
B	d5e0ib1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
B	d5e0ib3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
B	d5e0ib2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
D	d5e0id1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
D	d5e0id2	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
E	d5e0ie1	All alpha proteins	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	Hepatitis B viral capsid (hbcag)	automated matches	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
E	d5e0ie3	Artifacts	Tags	Tags	Tags	C-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)
E	d5e0ie2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HBV-D (Hepatitis B virus subtype adyw ) [TaxId: 10419 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Hepatitis B viral capsid (hbcag)	8086395	3000581	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Hepatitis_core	e5e0iC1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
F	Hepatitis_core	e5e0iF1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
A	Hepatitis_core	e5e0iA1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
B	Hepatitis_core	e5e0iB1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
D	Hepatitis_core	e5e0iD1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)
E	Hepatitis_core	e5e0iE1	A: alpha arrays	X: Hepatitis B viral capsid (hbcag) (From Topology)	H: Hepatitis B viral capsid (hbcag) (From Topology)	T: Hepatitis B viral capsid (hbcag)	F: Hepatitis_core	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
F	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
A	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
B	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
D	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)
E	1.10.4090.10	Mainly Alpha	Orthogonal Bundle	Hepatitis B viral capsid (hbcag) fold	Viral capsid, core domain supefamily, Hepatitis B virus	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00906	Hepatitis core antigen (Hepatitis_core)	Hepatitis core antigen	The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA [1]. There is some experimental evidence to support this [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Capsid protein	DNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity RNA binding identical protein binding protein binding	microtubule-dependent intracellular transport of viral material microtubule-dependent intracellular transport of viral material towards nucleus intracellular transport of virus viral process viral life cycle transport of virus transport of viral material towards nucleus biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host biological process involved in interaction with host biological process involved in symbiotic interaction viral penetration into host nucleus	viral capsid icosahedral viral capsid T=4 icosahedral viral capsid virion component host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036459	Viral capsid core domain supefamily, Hepatitis B virus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR002006	Hepatitis core antigen	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.