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Crystal structure of Dot1L in complex with inhibitor CPD10 [6'-chloro-1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)-1H-indol-1-yl)-[3,3'-bipyridin]-2(1H)-one] External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) B SCOP2B Superfamily S-adenosyl-L-methionine-dependent methyltransferases 8033656 3000118 SCOP2B (2022-06-29) A SCOP2B Superfamily S-adenosyl-L-methionine-dependent methyltransferases 8033656 3000118 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) B PF08123 e5dsxB1 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08123 ECOD (1.6) A PF08123 e5dsxA1 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF08123 ECOD (1.6)
Chains Accession Name Description Comments Source PF08123 Histone methylation protein DOT1 (DOT1) Histone methylation protein DOT1 The DOT1 domain regulates gene expression by methylating histone H3 [1]. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast [2]. Domain
Chains Polymer Molecular Function Biological Process Cellular Component Histone-lysine N-methyltransferase, H3 lysine-79 specific
Chains Drug Target   Associated Disease Pharos :  Q8TEK3