Annotations: 5DSE

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Hyccin repeat-like	8091062	3002479	SCOP2B (2022-06-29)
D	SCOP2 Family	Hyccin-like	8045610	4004564	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Hyccin repeat-like	8091061	3002479	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Hyccin repeat-like	8091062	3002479	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07719,PF19440	e5dseA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07719,PF19440	ECOD (1.6)
C	PF07719,PF19440	e5dseC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF07719,PF19440	ECOD (1.6)
B	PF09790	e5dseB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09790	ECOD (1.6)
D	PF09790	e5dseD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09790	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF19440	Tetratricopeptide repeat protein 7 N-terminal (TTC7_N)	Tetratricopeptide repeat protein 7 N-terminal	-	Repeat
A, C	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
A, C	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat
A, C	PF13424	Tetratricopeptide repeat (TPR_12)	Tetratricopeptide repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Tetratricopeptide repeat protein 7B	-	protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane
B, D	Hyccin	-	myelination developmental process multicellular organism development multicellular organismal process axon ensheathment ensheathment of neurons anatomical structure development cellular process nervous system development system development protein localization localization protein localization to cell periphery cellular localization myelination developmental process multicellular organism development multicellular organismal process axon ensheathment ensheathment of neurons anatomical structure development cellular process nervous system development system development protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process glycerolipid metabolic process lipid metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C	IPR045819	Tetratricopeptide repeat protein 7, N-terminal	Domain
A, C	IPR019734	Tetratricopeptide repeat	Repeat
B, D	IPR018619	Hyccin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q86TV6	astrocytic tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma ductal breast carcinoma in situ astrocytic tumor exocrine pancreatic carcinoma lung adenocarcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma
B, D	Pharos: Q9BYI3	hypomyelinating leukodystrophy 5 leukodystrophy intellectual disability cataract Mental deficiency pancreatic intraductal papillary-mucinous carcinoma peripheral neuropathy amyotrophic lateral sclerosis Sjogren syndrome breast carcinoma drug dependence substance-related disorder ductal breast carcinoma in situ hereditary spastic paraplegia invasive ductal breast carcinoma hypomyelinating leukodystrophy 5 leukodystrophy intellectual disability cataract Mental deficiency pancreatic intraductal papillary-mucinous carcinoma peripheral neuropathy amyotrophic lateral sclerosis Sjogren syndrome breast carcinoma drug dependence substance-related disorder ductal breast carcinoma in situ hereditary spastic paraplegia invasive ductal breast carcinoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor subependymal giant cell astrocytoma substance dependence facioscapulohumeral muscular dystrophy medulloblastoma myopathy ovarian cancer peripheral nervous system disease breast cancer substance abuse ulcerative colitis glioblastoma lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.