Annotations: 5DCP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00630	e5dcpA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00630	ECOD (1.6)
B	PF00630	e5dcpB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00630	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00630	Filamin/ABP280 repeat (Filamin)	Filamin/ABP280 repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Filamin-B	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding RNA binding organic cyclic compound binding nucleic acid binding cell adhesion molecule binding cadherin binding identical protein binding	developmental process epithelium development cellular developmental process cell development tissue development cell morphogenesis epithelial cell differentiation anatomical structure morphogenesis epithelial cell development epithelial cell morphogenesis cell differentiation anatomical structure development cellular process muscle structure development developmental process epithelium development cellular developmental process cell development tissue development cell morphogenesis epithelial cell differentiation anatomical structure morphogenesis epithelial cell development epithelial cell morphogenesis cell differentiation anatomical structure development cellular process muscle structure development skeletal muscle organ development skeletal muscle tissue development animal organ development muscle tissue development muscle organ development cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication response to organic substance biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cellular response to type II interferon response to biotic stimulus response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus cellular response to organic substance immune response response to other organism defense response defense response to symbiont response to external stimulus cellular response to chemical stimulus response to chemical immune system process defense response to other organism epidermal cell differentiation epidermis development keratinocyte development skin development keratinocyte differentiation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell periphery cell cortex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytosol intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle endocytic vesicle plasma membrane cluster of actin-based cell projections brush border actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B	IPR044801	Filamin family	Family
A, B	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A, B	IPR017868	Filamin/ABP280 repeat-like	Repeat
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR001298	Filamin/ABP280 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O75369	Boomerang dysplasia spondylocarpotarsal synostosis syndrome Larsen syndrome atelosteogenesis type I Larsen syndrome, dominant type atelosteogenesis atelosteogenesis type III myositis osteogenesis imperfecta rheumatoid arthritis systemic lupus erythematosus arthrogryposis atypical teratoid rhabdoid tumor Hashimoto thyroiditis malignant ependymoma Boomerang dysplasia spondylocarpotarsal synostosis syndrome Larsen syndrome atelosteogenesis type I Larsen syndrome, dominant type atelosteogenesis atelosteogenesis type III myositis osteogenesis imperfecta rheumatoid arthritis systemic lupus erythematosus arthrogryposis atypical teratoid rhabdoid tumor Hashimoto thyroiditis malignant ependymoma medulloblastoma non-small cell lung carcinoma ovarian cancer schizophrenia tuberculosis intellectual disability limited scleroderma mucopolysaccharidosis type 4 osteochondrodysplasia pancreatic intraductal papillary-mucinous neoplasm cataract lung carcinoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.