5DC4

CRYSTAL STRUCTURE OF MONOBODY AS25/ABL1 SH2 DOMAIN COMPLEX, CRYSTAL A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5dc4a_	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5dc4b_	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SH2 domain	8041216	3000197	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055103	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH2	e5dc4A1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
B	fn3	e5dc4B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
B	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tyrosine-protein kinase ABL1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding protein tyrosine kinase activity catalytic activity, acting on a protein cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups SH3 domain binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding DNA binding nucleic acid binding delta-catenin binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding ephrin receptor binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding DNA secondary structure binding four-way junction DNA binding bubble DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding magnesium ion binding adenylyltransferase activity nicotinate-nucleotide adenylyltransferase activity nucleotidyltransferase activity neuropilin binding SNARE binding syntaxin binding phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding proline-rich region binding actin monomer binding SH2 domain binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein kinase C binding	negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling negative regulation of long-term synaptic potentiation positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process negative regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication cellular process positive regulation of signaling response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process negative regulation of DNA repair nucleobase-containing compound metabolic process organic substance metabolic process cellular response to stress response to stress regulation of response to stress negative regulation of double-strand break repair negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process recombinational repair regulation of nucleobase-containing compound metabolic process negative regulation of double-strand break repair via homologous recombination double-strand break repair via homologous recombination DNA repair negative regulation of macromolecule metabolic process double-strand break repair negative regulation of response to stimulus negative regulation of metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination negative regulation of DNA recombination organic cyclic compound metabolic process DNA damage response regulation of response to stimulus metabolic process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process organonitrogen compound metabolic process macromolecule modification protein metabolic process protein modification process myoblast proliferation cell population proliferation regulation of tube diameter multicellular organismal process system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction blood circulation regulation of anatomical structure size cellular catabolic process catabolic process cellular metabolic process autophagy process utilizing autophagic mechanism epithelium migration tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility platelet-derived growth factor receptor-beta signaling pathway cell surface receptor signaling pathway platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway signal transduction enzyme-linked receptor protein signaling pathway cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion positive regulation of signal transduction regulation of signal transduction Wnt signaling pathway, planar cell polarity pathway positive regulation of response to stimulus positive regulation of non-canonical Wnt signaling pathway positive regulation of Wnt signaling pathway non-canonical Wnt signaling pathway Wnt signaling pathway positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Wnt signaling pathway regulation of non-canonical Wnt signaling pathway negative regulation of signaling negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade developmental process cellular developmental process hemopoiesis DN4 thymocyte differentiation cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process cell differentiation anatomical structure development T cell differentiation leukocyte differentiation positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion regulation of leukocyte differentiation regulation of developmental process regulation of leukocyte activation regulation of cell activation regulation of cell differentiation regulation of cell development regulation of T cell differentiation multicellular organism development regulation of immune system process regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T cell activation regulation of hemopoiesis regulation of lymphocyte activation regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly neuropilin signaling pathway response to oxidative stress cellular response to chemical stimulus cellular response to oxidative stress cellular response to chemical stress negative regulation of cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis system development morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation immune system development spleen development animal organ development hematopoietic or lymphoid organ development cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of molecular function positive regulation of kinase activity activation of protein kinase C activity regulation of kinase activity activation of protein kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of microtubule binding regulation of microtubule binding positive regulation of binding B cell proliferation involved in immune response immune response B cell activation B cell proliferation B cell activation involved in immune response cell activation involved in immune response leukocyte proliferation immune effector process mononuclear cell proliferation leukocyte activation involved in immune response lymphocyte proliferation lymphocyte activation involved in immune response cellular response to nitrogen compound response to dopamine response to organic substance cellular response to dopamine response to monoamine cellular response to endogenous stimulus response to catecholamine cellular response to catecholamine stimulus cellular response to organic substance response to organic cyclic compound response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to organonitrogen compound cellular response to monoamine stimulus regulation of oxidoreductase activity positive regulation of oxidoreductase activity response to endoplasmic reticulum stress positive regulation of canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction regulation of hematopoietic stem cell differentiation stem cell differentiation regulation of stem cell differentiation hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation response to epinephrine positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Cdc42 protein signal transduction regulation of Rho protein signal transduction Rho protein signal transduction Cdc42 protein signal transduction chromosome organization DNA conformation change protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization actin filament organization protein-containing complex assembly supramolecular fiber organization nervous system process neuromuscular process neuromuscular process controlling balance generation of neurons neurogenesis neuron differentiation regulation of modification of synaptic structure regulation of synapse organization regulation of synapse structure or activity synapse organization modification of synaptic structure axon extension regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization neuron projection development cell projection morphogenesis neuron projection morphogenesis developmental growth involved in morphogenesis plasma membrane bounded cell projection morphogenesis cell growth cell morphogenesis regulation of axon extension regulation of extent of cell growth regulation of cell size neuron projection extension regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation neuron development localization cellular localization establishment of localization in cell establishment of localization regulation of mitochondrial membrane potential membrane depolarization mitochondrial depolarization regulation of membrane potential branching morphogenesis of an epithelial tube angiogenesis regulation of vasculature development positive regulation of developmental process positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis blood vessel development regulation of morphogenesis of a branching structure blood vessel morphogenesis positive regulation of angiogenesis regulation of blood vessel branching vasculature development circulatory system development positive regulation of blood vessel branching branching involved in blood vessel morphogenesis positive regulation of vasculature development regulation of angiogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium neuron apoptotic process apoptotic process cell death programmed cell death regulation of neuron projection development dendrite development positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization positive regulation of dendrite development regulation of dendrite development regulation of plasma membrane bounded cell projection organization behavior learning learning or memory cognition associative learning podocyte apoptotic process epithelial cell apoptotic process regulation of calcium ion transport regulation of localization positive regulation of cation transmembrane transport positive regulation of calcium ion transport intracellular calcium ion homeostasis calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion cellular homeostasis positive regulation of transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process positive regulation of cell cycle mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle cell cycle regulation of cell cycle immune response-regulating cell surface receptor signaling pathway involved in phagocytosis import into cell immune response-regulating cell surface receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis vesicle-mediated transport immune response-activating signaling pathway Fc receptor signaling pathway immune response-regulating signaling pathway positive regulation of immune response phagocytosis Fc-gamma receptor signaling pathway positive regulation of immune system process immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway regulation of immune response endocytosis activation of immune response positive regulation of organelle organization regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly regulation of actin filament organization actomyosin structure organization positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of supramolecular fiber organization regulation of type II interferon production type II interferon production positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of type II interferon production positive regulation of gene expression positive regulation of cytokine production positive regulation of cellular biosynthetic process positive regulation of extracellular matrix organization extracellular matrix organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation protein autophosphorylation peptidyl-tyrosine autophosphorylation regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity establishment of lymphocyte polarity establishment of T cell polarity positive regulation of leukocyte cell-cell adhesion establishment or maintenance of cell polarity leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation positive regulation of establishment of T cell polarity positive regulation of leukocyte activation positive regulation of T cell activation establishment of cell polarity regulation of establishment of cell polarity regulation of leukocyte cell-cell adhesion heart development heart growth cardiac muscle tissue development cardiac muscle cell proliferation organ growth striated muscle tissue development muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation mismatch repair regulation of vesicle-mediated transport regulation of endocytosis positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway BMP signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway regulation of cellular response to growth factor stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular senescence ERBB signaling pathway epidermal growth factor receptor signaling pathway regulation of phospholipase activity negative regulation of hydrolase activity negative regulation of lipase activity negative regulation of molecular function negative regulation of catalytic activity negative regulation of phospholipase C activity negative regulation of phospholipase activity regulation of phospholipase C activity regulation of hydrolase activity regulation of lipase activity alpha-beta T cell differentiation alpha-beta T cell activation protein localization to microtubule cytoskeleton protein localization protein localization to microtubule end protein localization to microtubule plus-end protein localization to microtubule protein localization to cytoplasmic microtubule protein localization to cytoskeleton protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to cytoplasmic microtubule plus-end microspike assembly plasma membrane bounded cell projection assembly cell projection assembly positive regulation of locomotion regulation of cell motility regulation of lymphocyte migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration positive regulation of mononuclear cell migration regulation of mononuclear cell migration locomotion positive regulation of lymphocyte migration regulation of leukocyte migration positive regulation of T cell migration lymphocyte migration positive regulation of leukocyte migration leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration positive regulation of actin binding regulation of actin filament binding positive regulation of actin filament binding regulation of actin binding negative regulation of post-translational protein modification regulation of protein ubiquitination negative regulation of ubiquitin-protein transferase activity protein ubiquitination negative regulation of transferase activity negative regulation of protein modification process regulation of ubiquitin-protein transferase activity negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal transitional one stage B cell differentiation immature B cell differentiation transitional stage B cell differentiation B cell differentiation neuroepithelial cell differentiation columnar/cuboidal epithelial cell differentiation epithelial cell differentiation transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration positive regulation of epithelial cell migration blood vessel endothelial cell migration regulation of endothelial cell migration positive regulation of cell migration involved in sprouting angiogenesis regulation of epithelial cell migration regulation of cell migration involved in sprouting angiogenesis sprouting angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell migration positive regulation of cytosolic calcium ion concentration B cell receptor signaling pathway antigen receptor-mediated signaling pathway T cell receptor signaling pathway gland development thymus development signal transduction in response to DNA damage response to transforming growth factor beta cellular response to transforming growth factor beta stimulus cerebellum morphogenesis head development hindbrain morphogenesis brain development cerebellum development central nervous system development metencephalon development hindbrain development fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation integrin-mediated signaling pathway biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin astrocyte differentiation gliogenesis glial cell differentiation Bergmann glial cell differentiation regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization regulation of protein-containing complex assembly microtubule polymerization or depolymerization regulation of microtubule-based process microtubule polymerization regulation of microtubule polymerization regulation of protein polymerization microtubule-based process regulation of microtubule cytoskeleton organization cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide cellular response to reactive oxygen species apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway regulation of cellular senescence negative regulation of cellular metabolic process negative regulation of cellular senescence negative regulation of kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity negative regulation of phosphate metabolic process negative regulation of protein serine/threonine kinase activity negative regulation of protein kinase activity negative regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis B-1 B cell homeostasis homeostasis of number of cells lymphocyte homeostasis regulation of catabolic process regulation of autophagy regulation of cellular catabolic process activated T cell proliferation T cell proliferation post-embryonic development negative regulation of cell cycle negative regulation of mitotic cell cycle	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoskeleton membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen protein-containing complex nuclear body nucleoplasm somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection ruffle cell leading edge perinuclear region of cytoplasm cell body neuronal cell body postsynapse synapse cell junction mitochondrion growth cone axon distal axon site of polarized growth
B	AS25 monobody	enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity identical protein binding protein binding binding signaling receptor binding enzyme binding protease binding collagen binding protein-containing complex binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity identical protein binding protein binding binding signaling receptor binding enzyme binding protease binding collagen binding protein-containing complex binding cell adhesion molecule binding integrin binding structural molecule activity extracellular matrix structural constituent proteoglycan binding carbohydrate derivative binding heparin binding glycosaminoglycan binding sulfur compound binding	regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process negative regulation of transforming growth factor beta production regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development positive regulation of locomotion regulation of cell motility regulation of substrate-dependent cell migration, cell attachment to substrate positive regulation of biological process positive regulation of cell migration cell adhesion positive regulation of cell-substrate adhesion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion regulation of locomotion substrate-dependent cell migration substrate-dependent cell migration, cell attachment to substrate positive regulation of substrate-dependent cell migration, cell attachment to substrate cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly integrin activation cellular component organization or biogenesis positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process substrate adhesion-dependent cell spreading monocyte activation regulation of leukocyte activation cell activation regulation of cell activation negative regulation of monocyte activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation negative regulation of immune system process immune system process regulation of immune system process negative regulation of leukocyte activation axon extension positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size calcium-independent cell-matrix adhesion cell-matrix adhesion acute-phase response response to stimulus defense response response to stress inflammatory response acute inflammatory response response to wounding cellular response to stimulus regulation of signaling signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication ERK1 and ERK2 cascade signal transduction regulation of ERK1 and ERK2 cascade blood vessel morphogenesis tube development angiogenesis vasculature development tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development neural crest cell development mesenchyme development mesenchymal cell migration ameboidal-type cell migration autonomic nervous system development neural crest cell migration stem cell development neural crest cell differentiation tissue development stem cell differentiation neural crest cell migration involved in autonomic nervous system development mesenchymal cell differentiation formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development endoderm formation endodermal cell differentiation fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation integrin-mediated signaling pathway cell surface receptor signaling pathway positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling biological process involved in interspecies interaction between organisms biological process involved in interaction with symbiont biological process involved in symbiotic interaction regulation of cell shape regulation of cell morphogenesis cell junction organization cell junction assembly cell-substrate junction assembly cell-substrate junction organization wound healing regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process peptide cross-linking	basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen endoplasmic reticulum-Golgi intermediate compartment protein-containing complex fibrinogen complex apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane blood microparticle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR008266	Tyrosine-protein kinase, active site	Active Site
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR035837	Tyrosine-protein kinase ABL, SH2 domain	Domain
A	IPR000980	SH2 domain	Domain
A	IPR015015	F-actin binding	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B	IPR000562	Fibronectin type II domain	Domain
B	IPR000083	Fibronectin, type I	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR036943	Fibronectin type II domain superfamily	Homologous Superfamily
B	IPR013806	Kringle-like fold	Homologous Superfamily
B	IPR003961	Fibronectin type III	Domain
B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00519	chronic myelogenous leukemia, BCR-ABL1 positive congenital heart defects and skeletal malformations syndrome Failure to Thrive tubular adenocarcinoma adenocarcinoma liver cancer cancer esophageal cancer granular cell carcinoma breast carcinoma neoplasm of esophagus ovarian cancer cribriform carcinoma dermatofibrosarcoma protuberans abetalipoproteinemia chronic myelogenous leukemia, BCR-ABL1 positive congenital heart defects and skeletal malformations syndrome Failure to Thrive tubular adenocarcinoma adenocarcinoma liver cancer cancer esophageal cancer granular cell carcinoma breast carcinoma neoplasm of esophagus ovarian cancer cribriform carcinoma dermatofibrosarcoma protuberans abetalipoproteinemia hematologic disease astrocytic tumor lung large cell carcinoma Burkitt lymphoma childhood acute lymphoblastic leukemia congenital anemia pancreatic ductal adenocarcinoma congenital heart disease precancerous condition cribriform carcinoma of breast Down syndrome gastrointestinal stromal tumor systemic mastocytosis acute lymphoblastic leukemia idiopathic hypereosinophilic syndrome atypical teratoid rhabdoid tumor lymphatic system disease breast cancer malignant pancreatic neoplasm medulloblastoma chronic eosinophilic leukemia osteosarcoma tuberculosis acute T cell leukemia juvenile dermatomyositis liver neoplasm malignant ependymoma melanoma
B	Pharos: P02751	glioblastoma hypertensive disorder Crohn disease malignant mesothelioma aortic valve insufficiency breast carcinoma pulmonary fibrosis focal segmental glomerulosclerosis giant cell glioblastoma Mammary Neoplasms, Experimental carcinoma spondylometaphyseal dysplasia, 'corner fracture' type ureteral obstruction glomerulopathy with fibronectin deposits 2 heart disease glioblastoma hypertensive disorder Crohn disease malignant mesothelioma aortic valve insufficiency breast carcinoma pulmonary fibrosis focal segmental glomerulosclerosis giant cell glioblastoma Mammary Neoplasms, Experimental carcinoma spondylometaphyseal dysplasia, 'corner fracture' type ureteral obstruction glomerulopathy with fibronectin deposits 2 heart disease diabetes mellitus sarcomatoid carcinoma breast cancer ileocolitis ovarian cancer interstitial lung disease polycystic ovary syndrome kidney disease diabetic kidney disease limb-girdle muscular dystrophy schizophrenia Duchenne muscular dystrophy lung disease alcohol abuse transitional cell carcinoma endometriosis undifferentiated carcinoma atherosclerosis glomerulopathy with fibronectin deposits 1 autoimmune disease myocardial infarction oligodendroglioma colorectal cancer pancreatic ductal adenocarcinoma Crohn's colitis invasive ductal breast carcinoma primitive neuroectodermal tumor cystic fibrosis large cell medulloblastoma liver disease ductal breast carcinoma in situ malignant ependymoma tuberculosis fibronectin glomerulopathy gastric carcinoma arthritic joint disease atopic eczema Becker muscular dystrophy nasopharyngeal carcinoma breast disease hydrolethalus syndrome nephrosclerosis idiopathic interstitial pneumonia osteosarcoma coronary artery disease inborn carbohydrate metabolic disorder pilocytic astrocytoma juvenile dermatomyositis pterygium lung carcinoma adrenal cortex carcinoma Ehlers-Danlos syndrome malignant glioma ulcerative colitis Gaucher disease malignant pancreatic neoplasm astrocytic tumor mammary neoplasms, animal atypical teratoid rhabdoid tumor medulloblastoma hematologic disease cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.