5D28

Complex of GM-CSF/IL-2 inhibition factor with Granulocyte-macrophage colony-stimulating factor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5d28b_	All alpha proteins	4-helical cytokines	4-helical cytokines	Short-chain cytokines	automated matches	Sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
C	d5d28c_	All alpha proteins	4-helical cytokines	4-helical cytokines	Short-chain cytokines	automated matches	Sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	4-helical cytokines	8071888	3001717	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	4-helical cytokines	8071888	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF01109	e5d28B1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF01109	ECOD (1.6)
C	PF01109	e5d28C1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF01109	ECOD (1.6)
A	PF02250	e5d28A1	A: beta sandwiches	X: Soluble secreted chemokine inhibitor, VCCI (From Topology)	H: Soluble secreted chemokine inhibitor, VCCI (From Topology)	T: Soluble secreted chemokine inhibitor, VCCI	F: PF02250	ECOD (1.6)
D	PF02250	e5d28D1	A: beta sandwiches	X: Soluble secreted chemokine inhibitor, VCCI (From Topology)	H: Soluble secreted chemokine inhibitor, VCCI (From Topology)	T: Soluble secreted chemokine inhibitor, VCCI	F: PF02250	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
C	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, C	PF01109	Granulocyte-macrophage colony-stimulating factor (GM_CSF)	Granulocyte-macrophage colony-stimulating factor	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, C	Granulocyte-macrophage colony-stimulating factor	protein binding binding signaling receptor binding cytokine receptor binding growth factor receptor binding granulocyte macrophage colony-stimulating factor receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity cytokine activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular response to stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand response to stimulus signal transduction in absence of ligand negative regulation of signaling signaling regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway developmental process multicellular organismal process myeloid leukocyte differentiation cellular developmental process myeloid dendritic cell activation hemopoiesis cell activation cell development mononuclear cell differentiation myeloid leukocyte activation leukocyte activation myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation granulocyte differentiation neutrophil differentiation immune response cell population proliferation placenta development chordate embryonic development animal organ development embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development regulation of developmental process macrophage derived foam cell differentiation positive regulation of biological process regulation of cell differentiation positive regulation of developmental process foam cell differentiation positive regulation of cell differentiation regulation of macrophage derived foam cell differentiation positive regulation of macrophage derived foam cell differentiation positive regulation of cellular process response to organic substance response to granulocyte macrophage colony-stimulating factor response to cytokine cellular response to granulocyte macrophage colony-stimulating factor stimulus cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance macrophage differentiation positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process organonitrogen compound metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of interleukin-23 production interleukin-23 production positive regulation of gene expression positive regulation of multicellular organismal process regulation of interleukin-23 production positive regulation of cytokine production positive regulation of cellular biosynthetic process monocyte differentiation positive regulation of organelle organization positive regulation of cellular component organization regulation of cellular component organization non-membrane-bounded organelle assembly positive regulation of podosome assembly cellular component biogenesis cellular component organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly regulation of podosome assembly protein-containing complex assembly cellular component organization or biogenesis organelle assembly podosome assembly positive regulation of cellular component biogenesis protein-containing complex organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of organelle assembly positive regulation of organelle assembly cytokine-mediated signaling pathway granulocyte-macrophage colony-stimulating factor signaling pathway regulation of leukocyte proliferation positive regulation of cell population proliferation leukocyte proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex granulocyte macrophage colony-stimulating factor receptor complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex granulocyte macrophage colony-stimulating factor receptor complex receptor complex extracellular region extracellular space
A, D	GM-CSF/IL-2 inhibition factor	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, C	IPR000773	Granulocyte-macrophage colony-stimulating factor	Family
B, C	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
A, D	IPR036540	Poxvirus chemokine inhibitor superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.