5CZR

Crystal Structure of Human Protocadherin-24 EC1-2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cadherin	e5czrA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Cadherin	ECOD (1.6)
B	Cadherin	e5czrB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Cadherin	ECOD (1.6)
C	Cadherin	e5czrC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Cadherin	ECOD (1.6)
D	Cadherin	e5czrD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Cadherin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
B	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
C	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
D	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Cadherin-related family member 2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding protein binding	cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules cellular component biogenesis cellular component organization cellular component assembly brush border assembly intermicrovillar adhesion homotypic cell-cell adhesion cellular component organization or biogenesis developmental process epithelium development cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules cellular component biogenesis cellular component organization cellular component assembly brush border assembly intermicrovillar adhesion homotypic cell-cell adhesion cellular component organization or biogenesis developmental process epithelium development cellular developmental process cell differentiation anatomical structure development tissue development epithelial cell differentiation regulation of biological process regulation of growth regulation of cellular component organization regulation of cellular process response to stimulus negative regulation of biological process biological regulation growth negative regulation of cell growth detection of cell density detection of biotic stimulus regulation of cell growth cell growth response to biotic stimulus detection of stimulus negative regulation of growth negative regulation of cellular process contact inhibition negative regulation of cell growth involved in contact inhibition cell-cell adhesion mediated by cadherin plasma membrane bounded cell projection organization regulation of cellular component size cell projection organization regulation of cell projection organization regulation of cell projection size regulation of microvillus length microvillus organization regulation of microvillus organization regulation of biological quality regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection actin-based cell projection microvillus plasma membrane bounded cell projection microvillus membrane cell projection membrane brush border membrane cluster of actin-based cell projections brush border anchoring junction cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039808	Cadherin	Family
A, B, C, D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A, B, C, D	IPR020894	Cadherin conserved site	Conserved Site
A, B, C, D	IPR002126	Cadherin-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9BYE9	Crohn disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.