5CZO

Structure of S. cerevisiae Hrr25:Mam1 complex, form 2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth C]	SCOP2B Superfamily	MAM1 domain-like	8053449	3002189	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	MAM1 domain-like	8053449	3002189	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e5czoA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C [auth B]	Pkinase_Tyr	e5czoB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B [auth C]	MAM1	e5czoC1	A: alpha arrays	X: Monopolin complex subunit MAM1 (From Topology)	H: Monopolin complex subunit MAM1 (From Topology)	T: Monopolin complex subunit MAM1	F: MAM1	ECOD (1.6)
D	MAM1	e5czoD1	A: alpha arrays	X: Monopolin complex subunit MAM1 (From Topology)	H: Monopolin complex subunit MAM1 (From Topology)	T: Monopolin complex subunit MAM1	F: MAM1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B [auth C], D	PF10434	Monopolin complex protein MAM1 (MAM1)	Monopolin complex protein MAM1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Casein kinase I homolog HRR25	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding protein binding	regulation of localization regulation of cellular component organization regulation of cellular process transport membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle-mediated transport regulation of vesicle fusion with Golgi apparatus vesicle organization cellular component organization regulation of Golgi organization localization vesicle fusion with Golgi apparatus regulation of localization regulation of cellular component organization regulation of cellular process transport membrane fusion organelle membrane fusion regulation of vesicle fusion vesicle-mediated transport regulation of vesicle fusion with Golgi apparatus vesicle organization cellular component organization regulation of Golgi organization localization vesicle fusion with Golgi apparatus cellular component organization or biogenesis Golgi organization endomembrane system organization membrane organization regulation of biological process regulation of transport biological regulation regulation of vesicle-mediated transport establishment of localization regulation of organelle organization organelle fusion organelle organization cellular process vesicle fusion Golgi vesicle transport catabolic process macroautophagy autophagy autophagosome organization cellular component biogenesis cellular catabolic process cellular component assembly process utilizing autophagic mechanism autophagosome assembly organelle assembly vacuole organization cellular metabolic process regulation of autophagosome assembly regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle assembly metabolic process import into cell endocytosis autophagy of peroxisome pexophagy cellular response to stimulus response to stimulus signaling signal transduction cell communication ribosome biogenesis ribonucleoprotein complex biogenesis ribosomal large subunit biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization protein targeting establishment of protein localization to vacuole cytoplasm to vacuole targeting by the Cvt pathway cellular macromolecule localization establishment of localization in cell protein targeting to vacuole regulation of intracellular transport regulation of protein localization by the Cvt pathway organic substance transport regulation of establishment of protein localization intracellular transport protein localization to vacuole regulation of protein transport regulation of vacuolar transport establishment of protein localization to organelle protein transport regulation of cellular localization regulation of protein targeting macromolecule localization protein localization to organelle regulation of intracellular protein transport vacuolar transport intracellular protein transport primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress macromolecule metabolic process DNA repair ribosomal small subunit biogenesis regulation of ER to Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport cellular biosynthetic process RNA metabolic process tRNA wobble uridine modification tRNA processing organic substance biosynthetic process tRNA wobble base modification RNA processing tRNA modification gene expression macromolecule biosynthetic process tRNA metabolic process RNA modification biosynthetic process ncRNA metabolic process macromolecule modification nucleic acid catabolic process phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process nuclear division nuclear chromosome segregation meiotic nuclear division cell cycle chromosome segregation cell cycle process establishment of organelle localization attachment of meiotic spindle microtubules to kinetochore metaphase chromosome alignment meiotic metaphase I homologous chromosome alignment meiosis I chromosome localization organelle localization attachment of spindle microtubules to kinetochore spindle attachment to meiosis I kinetochore meiosis I cell cycle process meiotic metaphase chromosome alignment homologous chromosome segregation establishment of chromosome localization positive regulation of cellular component organization positive regulation of biological process positive regulation of endocytosis clathrin-dependent endocytosis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of receptor-mediated endocytosis positive regulation of transport positive regulation of clathrin-dependent endocytosis receptor-mediated endocytosis regulation of clathrin-dependent endocytosis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cellular bud cellular bud tip site of polarized growth monopolin complex protein-containing complex chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm cytosol cell periphery plasma membrane membrane nucleoplasm Golgi apparatus endomembrane system preribosome ribonucleoprotein complex preribosome, small subunit precursor microtubule organizing center cytoskeleton spindle pole body microtubule cytoskeleton cellular bud neck
B [auth C], D	Monopolin complex subunit MAM1	-	meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization nuclear chromosome segregation cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization nuclear chromosome segregation cellular process meiotic nuclear division cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process meiotic sister chromatid cohesion involved in meiosis I chromosome organization sister chromatid cohesion meiotic sister chromatid cohesion establishment of organelle localization cellular localization attachment of meiotic spindle microtubules to kinetochore metaphase chromosome alignment localization meiotic metaphase I homologous chromosome alignment meiosis I chromosome localization organelle localization establishment of localization in cell attachment of spindle microtubules to kinetochore spindle attachment to meiosis I kinetochore establishment of localization meiosis I cell cycle process meiotic metaphase chromosome alignment homologous chromosome segregation establishment of chromosome localization	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle monopolin complex intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle monopolin complex protein-containing complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, C [auth B]	IPR000719	Protein kinase domain	Domain
A, C [auth B]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, C [auth B]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B [auth C], D	IPR018847	Monopolin complex, subunit Mam1	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, C [auth B]	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084
B [auth C], D	MLY	Parent Component: LYS RESID: AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.