Annotations: 5CW7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21217	e5cw7A1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
G	PF21217	e5cw7G1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
I	PF21217	e5cw7I1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
K	PF21217	e5cw7K1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
M	PF21217	e5cw7M1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
C	PF21217	e5cw7C1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
E	PF21217	e5cw7E1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
O	PF21217	e5cw7O1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF21217	ECOD (1.6)
B	PF05016	e5cw7B1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
D	PF05016	e5cw7D1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
F	PF05016	e5cw7F1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
H	PF05016	e5cw7H1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
J	PF05016	e5cw7J1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
N	PF05016	e5cw7N1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
P	PF05016	e5cw7P1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
L	PF05016	e5cw7L1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
D	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
F	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
H	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
J	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
N	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
P	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
L	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M, O	PF21217	Stability determinant (PaaA2)	Stability determinant	-	Family
B, D, F, H, J B, D, F, H, J, L, N, P	PF05016	ParE toxin of type II toxin-antitoxin system, parDE (ParE_toxin)	ParE toxin of type II toxin-antitoxin system, parDE	ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralised by the antitoxin ParD. The family also encompasses RelE/ParE described in [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	PAAA2	molecular adaptor activity	-	-
B, D, F, H, J B, D, F, H, J, L, N, P	Plasmid stabilization protein ParE	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O	IPR048851	Stability determinant domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P	IPR007712	Toxin-antitoxin system, RelE/ParE toxin family	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR035093	Toxin-antitoxin system, RelE/ParE toxin domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.