5CTR

Crystal structure of human SART3 HAT-C domain-human USP4 DUSP-UBL domain complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Suf	e5ctrA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Suf	ECOD (1.6)
B	Suf	e5ctrB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Suf	ECOD (1.6)
C	Ubiquitin_3	e5ctrC2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Ubiquitin_3	ECOD (1.6)
C	DUSP	e5ctrC1	A: a+b complex topology	X: DUSP, domain in ubiquitin-specific proteases (From Topology)	H: DUSP, domain in ubiquitin-specific proteases (From Topology)	T: DUSP, domain in ubiquitin-specific proteases	F: DUSP	ECOD (1.6)
D	Ubiquitin_3	e5ctrD2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Ubiquitin_3	ECOD (1.6)
D	DUSP	e5ctrD1	A: a+b complex topology	X: DUSP, domain in ubiquitin-specific proteases (From Topology)	H: DUSP, domain in ubiquitin-specific proteases (From Topology)	T: DUSP, domain in ubiquitin-specific proteases	F: DUSP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.2230.10	Alpha Beta	2-Layer Sandwich	DUSP-like	DUSP-like	CATH (4.3.0)
C	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
D	3.30.2230.10	Alpha Beta	2-Layer Sandwich	DUSP-like	DUSP-like	CATH (4.3.0)
D	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF14836	Ubiquitin-like domain (Ubiquitin_3)	Ubiquitin-like domain	This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases [1] and in gametogenetin-binding protein.	Domain
C, D	PF06337	DUSP domain (DUSP)	DUSP domain	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporti ...	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Squamous cell carcinoma antigen recognized by T-cells 3	protein binding binding histone binding RNA binding U6 snRNA binding snRNA binding organic cyclic compound binding nucleic acid binding U4 snRNA binding ubiquitin-specific protease binding enzyme binding protease binding U6atac snRNA binding	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process ribonucleoprotein complex biogenesis RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly primary metabolic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile protein-DNA complex assembly protein-DNA complex organization chromatin organization chromatin remodeling nucleosome assembly nucleosome organization anatomical structure morphogenesis cell morphogenesis transcription elongation by RNA polymerase II RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II transcription elongation-coupled chromatin remodeling nucleobase-containing compound biosynthetic process DNA-templated transcription elongation organic cyclic compound biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm Cajal body ASAP complex protein-containing complex
C, D	Ubiquitin carboxyl-terminal hydrolase 4	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity protein binding binding signaling receptor binding G protein-coupled receptor binding adenosine receptor binding cation binding cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity protein binding binding signaling receptor binding G protein-coupled receptor binding adenosine receptor binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling regulation of protein stability regulation of biological quality negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process organic substance metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization protein deubiquitination protein modification by small protein removal ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly cellular metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, B	IPR008669	LSM-interacting domain	Domain
A, B	IPR034218	SART3, RNA recognition motif 2	Domain
A, B	IPR034217	SART3, RNA recognition motif 1	Domain
A, B	IPR000504	RNA recognition motif domain	Domain
A, B	IPR003107	HAT (Half-A-TPR) repeat	Repeat
A, B	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A, B	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
C, D	IPR028889	Ubiquitin specific protease domain	Domain
C, D	IPR028135	Ubiquitin-like domain, USP-type	Domain
C, D	IPR035927	DUSP-like superfamily	Homologous Superfamily
C, D	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
C, D	IPR006615	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	Domain
C, D	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain
C, D	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q15020	acute myeloid leukemia dermatomyositis large cell medulloblastoma malignant glioma osteosarcoma tuberculosis adrenal cortex carcinoma diabetes mellitus lung adenocarcinoma malignant mesothelioma ovarian cancer astrocytic tumor juvenile dermatomyositis lung cancer medulloblastoma acute myeloid leukemia dermatomyositis large cell medulloblastoma malignant glioma osteosarcoma tuberculosis adrenal cortex carcinoma diabetes mellitus lung adenocarcinoma malignant mesothelioma ovarian cancer astrocytic tumor juvenile dermatomyositis lung cancer medulloblastoma primary cutaneous T-cell non-Hodgkin lymphoma
C, D	Pharos: Q13107	astrocytic tumor endometriosis osteosarcoma cancer heart disease ovarian cancer endogenous depression large cell medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.