5CO1

Crystal Structure of Zebrafish Protocadherin-19 EC3-4

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cadherin-like	8091911	3002049	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cadherin-like	8091912	3002049	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cadherin-like	8091911	3002049	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cadherin-like	8091912	3002049	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cadherin-like	8091911	3002049	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cadherin-like	8091912	3002049	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cadherin-like	8091911	3002049	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cadherin-like	8091912	3002049	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00028	e5co1A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
C	PF00028	e5co1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
D	PF00028	e5co1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
B	PF00028	e5co1B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
C	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
D	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)
B	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protocadherin-19 isoform 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding protein binding identical protein binding	multicellular organismal process regulation of action potential regulation of biological process system process regulation of cellular process nervous system process regulation of system process biological regulation action potential transmission of nerve impulse cell communication regulation of nervous system process neuronal action potential regulation of transmission of nerve impulse regulation of cell communication multicellular organismal process regulation of action potential regulation of biological process system process regulation of cellular process nervous system process regulation of system process biological regulation action potential transmission of nerve impulse cell communication regulation of nervous system process neuronal action potential regulation of transmission of nerve impulse regulation of cell communication cellular process regulation of multicellular organismal process regulation of biological quality regulation of neuronal action potential regulation of membrane potential cellular response to stimulus regulation of postsynaptic membrane potential response to stimulus signaling chemical synaptic transmission, postsynaptic synaptic signaling signal transduction trans-synaptic signaling cell surface receptor signaling pathway cell-cell signaling chemical synaptic transmission anterograde trans-synaptic signaling excitatory postsynaptic potential cell adhesion sensory perception of light stimulus sensory perception visual perception developmental process head development brain morphogenesis animal organ development brain development nervous system development multicellular organism development anatomical structure morphogenesis central nervous system development anatomical structure development animal organ morphogenesis system development cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis neural tube formation anatomical structure formation involved in morphogenesis	membrane cellular anatomical entity cell periphery plasma membrane postsynapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013164	Cadherin, N-terminal	Domain
A, B, C, D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A, B, C, D	IPR020894	Cadherin conserved site	Conserved Site
A, B, C, D	IPR002126	Cadherin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.