5CKR

Crystal Structure of MraY in complex with Muraymycin D2

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MraY-like	8045121	3002333	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glycos_transf_4	e5ckrA1	A: alpha bundles	X: Bacterial cell wall synthesis membrane enzyme MraY-related (From Topology)	H: Bacterial cell wall synthesis membrane enzyme MraY-related (From Topology)	T: Bacterial cell wall synthesis membrane enzyme MraY-related	F: Glycos_transf_4	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00953	Glycosyl transferase family 4 (Glycos_transf_4)	Glycosyl transferase family 4	-	Family
A	PF10555	Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 (MraY_sig1)	Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phospho-N-acetylmuramoyl-pentapeptide-transferase	transferase activity phospho-N-acetylmuramoyl-pentapeptide-transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis cellular process cell cycle cell division developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis cellular process cell cycle cell division cellular component organization cell wall organization or biogenesis cell wall organization cellular component organization or biogenesis external encapsulating structure organization cellular biosynthetic process cellular metabolic process macromolecule biosynthetic process cellular component biogenesis organic substance metabolic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process glycosaminoglycan metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process peptidoglycan metabolic process glycosaminoglycan biosynthetic process carbohydrate derivative biosynthetic process peptidoglycan-based cell wall biogenesis organonitrogen compound metabolic process peptidoglycan biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018480	Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site	Conserved Site
A	IPR003524	Phospho-N-acetylmuramoyl-pentapeptide transferase	Family
A	IPR000715	Glycosyl transferase, family 4	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Glycosyl transferase family 4	Transmembrane glycosyl transferase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	PNPT Superfamily	MraY translocase in complex with Muraymycin D2

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.