Annotations: 5CKQ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00431	e5ckqA1	A: beta sandwiches	X: jelly-roll	H: Spermadhesin, CUB domain (From Topology)	T: Spermadhesin, CUB domain	F: PF00431	ECOD (1.6)
A	PF14670	e5ckqA3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF14670	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.290	Mainly Beta	Sandwich	Jelly Rolls	Spermadhesin, CUB domain	CATH (4.3.0)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07645	Calcium-binding EGF domain (EGF_CA)	Calcium-binding EGF domain	-	Domain
A	PF00431	CUB domain (CUB)	CUB domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mannan-binding lectin serine protease 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity calcium-dependent protein binding serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process complement activation, lectin pathway humoral immune response biological process involved in interspecies interaction between organisms response to stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process complement activation, lectin pathway regulation of biological process immune response response to other organism defense response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response activation of immune response zymogen activation organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR000859	CUB domain	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.