5CJQ

Crystal structure of a trimeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth L]PF07654e5cjqL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
A [auth L]PF07686e5cjqL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
B [auth H]PF07654e5cjqH3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
B [auth H]PF07686e5cjqH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
D [auth B]PF00509e5cjqB1 A: alpha bundlesX: Hemagglutinin HA2 chain (From Topology)H: Hemagglutinin HA2 chain (From Topology)T: Hemagglutinin HA2 chainF: PF00509ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D [auth B]3.90.20.10 Alpha Beta Alpha-Beta Complex Hemagglutinin Ectodomain Chain BCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth L]CR9114, anti-influenza hemagglutinin, neutralizing L-LAMBDA Homo sapiens (human) IGLV1-44*01, IGLJ7*01, IGLC2*01, IGLC2*02, IGLC3*04 V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA IG FAB-GAMMA-1_LAMBDA IMGT (202416-0)
B [auth H]CR9114, anti-influenza hemagglutinin, neutralizing VH-CH1 Homo sapiens (human) IGHV1-69*01, IGHV1-69*06, IGHV1-69*12, IGHV1-69*13, IGHV1-69*14, IGHV1-69D*01, IGHJ6*01, IGHJ6*02, IGHG1*03 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_LAMBDA IMGT (202416-0)