5C7F

Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal domain (1-209) in complex with Arabidopsis IAA1 peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF17814	e5c7fC3	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
C	PF21889	e5c7fC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: PF21889	ECOD (1.6)
C	PF21359	e5c7fC2	A: few secondary structure elements	X: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	H: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Zinc finger domain in TOPLESS related protein 2 (TPR2)	F: PF21359	ECOD (1.6)
D	PF17814	e5c7fD2	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
D	PF21889	e5c7fD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: PF21889	ECOD (1.6)
D	PF21359	e5c7fD3	A: few secondary structure elements	X: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	H: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Zinc finger domain in TOPLESS related protein 2 (TPR2)	F: PF21359	ECOD (1.6)
A	PF17814	e5c7fA2	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
A	PF21889	e5c7fA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: PF21889	ECOD (1.6)
A	PF21359	e5c7fA1	A: few secondary structure elements	X: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	H: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Zinc finger domain in TOPLESS related protein 2 (TPR2)	F: PF21359	ECOD (1.6)
B	PF17814	e5c7fB1	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
B	PF21889	e5c7fB3	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: PF21889	ECOD (1.6)
B	PF21359	e5c7fB2	A: few secondary structure elements	X: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	H: Zinc finger domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Zinc finger domain in TOPLESS related protein 2 (TPR2)	F: PF21359	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF21359	TOPLESS, zinc finger domain (zf_topless)	TOPLESS, zinc finger domain	This is the zinc finger domain of TOPLESS and TOPLESS-related proteins, plant transcriptional co-repressors [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ASPR2 protein	molecular sequestering activity protein sequestering activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction response to stimulus pattern recognition receptor signaling pathway regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response regulation of immune response activation of innate immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus signaling positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus positive regulation of cellular process regulation of signaling positive regulation of innate immune response defense response defense response to symbiont immune system process regulation of cell communication positive regulation of signaling	cell periphery plasma membrane membrane cellular anatomical entity
E, F, G, H	Auxin-responsive protein IAA1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity identical protein binding protein binding	auxin-activated signaling pathway cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus signaling response to endogenous stimulus biological regulation hormone-mediated signaling pathway cellular response to auxin stimulus cell communication response to auxin cellular response to endogenous stimulus cellular response to chemical stimulus auxin-activated signaling pathway cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus signaling response to endogenous stimulus biological regulation hormone-mediated signaling pathway cellular response to auxin stimulus cell communication response to auxin cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular process cellular response to organic substance signal transduction cellular response to hormone stimulus	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR019775	WD40 repeat, conserved site	Conserved Site
A, B, C, D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR006595	CTLH, C-terminal LisH motif	Domain
A, B, C, D	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily	Homologous Superfamily
A, B, C, D	IPR048419	TOPLESS, zinc finger domain	Domain
A, B, C, D	IPR001680	WD40 repeat	Repeat
A, B, C, D	IPR027728	Topless family	Family
A, B, C, D	IPR006594	LIS1 homology motif	Conserved Site
A, B, C, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
E, F, G, H	IPR003311	AUX/IAA protein	Family
E, F, G, H	IPR033389	AUX/IAA domain	Domain
E, F, G, H	IPR000270	PB1 domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.