5C59

Crystal structure of the periplasmic region of MacB from E. coli

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GBAA_5634-like	8106449	3002779	SCOP2B (2022-06-29)
B	SCOP2 Family	MacB periplasmic domain-like	8047806	4005830	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	GBAA_5634-like	8106449	3002779	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	GBAA_5634-like	8106449	3002779	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GBAA_5634-like	8106449	3002779	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GBAA_5634-like	8106449	3002779	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12704	e5c59A2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
A	F_UNCLASSIFIED	e5c59A1	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF12704	e5c59B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
B	F_UNCLASSIFIED	e5c59B2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF12704	e5c59C2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
C	F_UNCLASSIFIED	e5c59C1	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF12704	e5c59D2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
D	F_UNCLASSIFIED	e5c59D1	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF12704	e5c59E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
F	PF12704	e5c59F1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
F	F_UNCLASSIFIED	e5c59F2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF12704	e5c59G1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF12704	ECOD (1.6)
G	F_UNCLASSIFIED	e5c59G2	A: a+b two layers	X: Alpha-beta plaits	H: ferredoxin-like domain in periplasmic region of MacB (From Topology)	T: ferredoxin-like domain in periplasmic region of MacB	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G	PF12704	MacB-like periplasmic core domain (MacB_PCD)	MacB-like periplasmic core domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G	Macrolide export ATP-binding/permease protein MacB	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	response to stimulus response to chemical response to antibiotic	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR017871	ABC transporter-like, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G	IPR017911	MacB-like, ATP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR003838	ABC3 transporter permease protein domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR025857	MacB-like periplasmic core domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.