5BP4

Modifying region (DH-ER-KR) of a mycocerosic acid synthase-like (MAS-like) PKS

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
K	SCOP2 Family	Alcohol dehydrogenase-like	8055970	4000010	SCOP2 (2022-06-29)
K	SCOP2 Family	Ketoreductase module of polyketide syntase	8055966	4000119	SCOP2 (2022-06-29)
K	SCOP2 Family	Ketoreductase module of polyketide syntase	8055967	4000119	SCOP2 (2022-06-29)
K	SCOP2 Family	PKS dehydratase-like	8050552	4006953	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	GroES-like	8055971	3000002	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	SDR-like	8055968	3000038	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	SDR-like	8055969	3000038	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2 (2022-06-29)
L	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	SDR-like	8055969	3000038	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	SDR-like	8055968	3000038	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055965	3000149	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	GroES-like	8055971	3000002	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055964	3000149	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055972	3000040	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	PF08240	e5bp4G3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
G	PF14765	e5bp4G4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
G	PF21089	e5bp4G1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
G	F_UNCLASSIFIED	e5bp4G2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00107	e5bp4G6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
G	PF08659	e5bp4G5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
Q	PF08240	e5bp4Q4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
Q	PF14765	e5bp4Q2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
Q	PF21089	e5bp4Q3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
Q	PF00107	e5bp4Q1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
A	PF08240	e5bp4A4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
A	PF14765	e5bp4A2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
A	PF21089	e5bp4A1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
A	F_UNCLASSIFIED	e5bp4A3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00107	e5bp4A5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
A	PF08659	e5bp4A6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
B	PF08240	e5bp4B3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
B	PF14765	e5bp4B6	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
B	PF21089	e5bp4B5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
B	F_UNCLASSIFIED	e5bp4B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00107	e5bp4B4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
B	PF08659	e5bp4B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
C	PF08240	e5bp4C1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
C	PF14765	e5bp4C5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
C	PF21089	e5bp4C3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
C	F_UNCLASSIFIED	e5bp4C6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00107	e5bp4C4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
C	PF08659	e5bp4C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
D	PF08240	e5bp4D2	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
D	PF14765	e5bp4D4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
D	PF21089	e5bp4D5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
D	F_UNCLASSIFIED	e5bp4D6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00107	e5bp4D1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
D	PF08659	e5bp4D3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
E	PF08240	e5bp4E3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
E	PF14765	e5bp4E2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
E	PF21089	e5bp4E1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
E	F_UNCLASSIFIED	e5bp4E5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00107	e5bp4E4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
E	PF08659	e5bp4E6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
F	PF08240	e5bp4F4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
F	PF14765	e5bp4F6	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
F	PF21089	e5bp4F2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
F	F_UNCLASSIFIED	e5bp4F3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF00107	e5bp4F5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
F	PF08659	e5bp4F1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
H	PF08240	e5bp4H1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
H	PF14765	e5bp4H4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
H	PF21089	e5bp4H5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
H	F_UNCLASSIFIED	e5bp4H3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF00107	e5bp4H6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
H	PF08659	e5bp4H2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
I	PF08240	e5bp4I4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
I	PF14765	e5bp4I2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
I	PF21089	e5bp4I3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
I	PF00107	e5bp4I1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
J	PF08240	e5bp4J2	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
J	PF14765	e5bp4J3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
J	PF21089	e5bp4J6	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
J	F_UNCLASSIFIED	e5bp4J1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
J	PF00107	e5bp4J5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
J	PF08659	e5bp4J4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
K	PF08240	e5bp4K3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
K	PF14765	e5bp4K5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
K	PF21089	e5bp4K2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
K	F_UNCLASSIFIED	e5bp4K4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF00107	e5bp4K1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
K	PF08659	e5bp4K6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
L	PF08240	e5bp4L5	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
L	PF14765	e5bp4L3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
L	PF21089	e5bp4L4	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
L	PF00107	e5bp4L2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
L	PF08659	e5bp4L1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
M	PF08240	e5bp4M5	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
M	PF14765	e5bp4M6	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
M	PF21089	e5bp4M2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
M	F_UNCLASSIFIED	e5bp4M4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
M	PF00107	e5bp4M3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
M	PF08659	e5bp4M1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
N	PF08240	e5bp4N4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
N	PF14765	e5bp4N3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
N	PF21089	e5bp4N5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
N	F_UNCLASSIFIED	e5bp4N1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
N	PF00107	e5bp4N2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
N	PF08659	e5bp4N6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
O	PF08240	e5bp4O4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
O	PF14765	e5bp4O2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
O	PF21089	e5bp4O3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
O	PF00107	e5bp4O1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
P	PF08240	e5bp4P3	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
P	PF14765	e5bp4P2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
P	PF21089	e5bp4P5	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
P	F_UNCLASSIFIED	e5bp4P4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: F_UNCLASSIFIED	ECOD (1.6)
P	PF00107	e5bp4P6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
P	PF08659	e5bp4P1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF08659	ECOD (1.6)
R	PF08240	e5bp4R4	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240	ECOD (1.6)
R	PF14765	e5bp4R2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF14765	ECOD (1.6)
R	PF21089	e5bp4R3	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF21089	ECOD (1.6)
R	PF00107	e5bp4R1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF13602	Zinc-binding dehydrogenase (ADH_zinc_N_2)	Zinc-binding dehydrogenase	-	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF21089	Polyketide synthase dehydratase domain (PKS_DH_N)	Polyketide synthase dehydratase domain	This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF08240	Alcohol dehydrogenase GroES-like domain (ADH_N)	Alcohol dehydrogenase GroES-like domain	This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF08659	KR domain (KR)	KR domain	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	PF14765	Polyketide synthase dehydratase N-terminal domain (PS-DH)	Polyketide synthase dehydratase N-terminal domain	This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and ...	This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	Mycocerosic acid synthase	oxidoreductase activity catalytic activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR020807	Polyketide synthase, dehydratase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR049551	Polyketide synthase, dehydratase domain, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR014043	Acyl transferase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily