5B3Z

Crystal structure of hPin1 WW domain (5-39) fused with maltose-binding protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5b3za1	Alpha and beta proteins (a/b)	Periplasmic binding protein-like II	Periplasmic binding protein-like II	Phosphate binding protein-like	D-maltodextrin-binding protein, MBP	Human (Homo sapiens ) [TaxId: 9606 ], (Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d5b3za2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ], (Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d5b3zb_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like II	Periplasmic binding protein-like II	Phosphate binding protein-like	D-maltodextrin-binding protein, MBP	Human (Homo sapiens ) [TaxId: 9606 ], (Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d5b3zc_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like II	Periplasmic binding protein-like II	Phosphate binding protein-like	D-maltodextrin-binding protein, MBP	Human (Homo sapiens ) [TaxId: 9606 ], (Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d5b3zd_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like II	Periplasmic binding protein-like II	Phosphate binding protein-like	D-maltodextrin-binding protein, MBP	Human (Homo sapiens ) [TaxId: 9606 ], (Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WW	e5b3zA3	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)
A	SBP_bac_1_C	e5b3zA2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C	ECOD (1.6)
A	SBP_bac_1_N_1	e5b3zA1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_N_1	ECOD (1.6)
B	WW	e5b3zB3	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)
B	SBP_bac_1_C	e5b3zB1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C	ECOD (1.6)
B	SBP_bac_1_N_1	e5b3zB2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_N_1	ECOD (1.6)
C	WW	e5b3zC3	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)
C	SBP_bac_1_C	e5b3zC1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C	ECOD (1.6)
C	SBP_bac_1_N_1	e5b3zC2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_N_1	ECOD (1.6)
D	WW	e5b3zD3	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)
D	SBP_bac_1_C	e5b3zD2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C	ECOD (1.6)
D	SBP_bac_1_N_1	e5b3zD1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_N_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01547	Bacterial extracellular solute-binding protein (SBP_bac_1)	Bacterial extracellular solute-binding protein	-	Family
A, B, C, D	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1,Maltose-binding periplasmic protein	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding phosphoprotein binding protein binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding phosphoprotein binding protein binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding cytoskeletal motor activity isomerase activity catalytic activity cis-trans isomerase activity cytoskeletal protein binding tau protein binding catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity enzyme regulator activity ubiquitin ligase activator activity enzyme activator activity ubiquitin-protein transferase regulator activity molecular function activator activity molecular function regulator activity ubiquitin-protein transferase activator activity phosphoserine residue binding protein phosphorylated amino acid binding GTPase activating protein binding phosphothreonine residue binding beta-catenin binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility locomotion localization transport organic substance transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport response to organic substance response to disaccharide response to oxygen-containing compound detection of maltose stimulus detection of stimulus response to carbohydrate detection of chemical stimulus detection of disaccharide stimulus response to maltose detection of carbohydrate stimulus regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade protein localization regulation of localization cellular localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus regulation of cellular localization cellular macromolecule localization protein localization to organelle cell surface receptor protein serine/threonine kinase signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway SMAD protein signal transduction regulation of SMAD protein signal transduction negative regulation of SMAD protein signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process negative regulation of transforming growth factor beta receptor signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway amyloid precursor protein catabolic process regulation of amide metabolic process regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process regulation of primary metabolic process negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process protein metabolic process amide metabolic process amyloid precursor protein metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of macromolecule metabolic process negative regulation of amyloid-beta formation organonitrogen compound metabolic process negative regulation of amide metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process mitotic nuclear division regulation of cellular component organization organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle cellular component organization regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cellular component organization or biogenesis response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus catabolic process macromolecule catabolic process negative regulation of protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process protein catabolic process regulation of catabolic process organic substance catabolic process regulation of protein catabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process positive regulation of molecular function positive regulation of protein binding positive regulation of binding positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization developmental process multicellular organismal process cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development system development cell junction organization synapse organization negative regulation of locomotion regulation of cell motility regulation of locomotion negative regulation of cell motility regulation of protein modification process regulation of protein phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein phosphorylation phosphorylation regulation of phosphorylation regulation of phosphorus metabolic process protein dephosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation positive regulation of phosphorylation positive regulation of protein phosphorylation positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway positive regulation of signaling	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space outer membrane-bounded periplasmic space cell envelope membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol synapse cell junction glutamatergic synapse cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle midbody cytosolic region postsynapse postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR006061	Solute-binding family 1, conserved site	Conserved Site
A, B, C, D	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
A, B, C, D	IPR006059	Bacterial-type extracellular solute-binding protein	Family
A, B, C, D	IPR036020	WW domain superfamily	Homologous Superfamily
A, B, C, D	IPR023058	Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site	Conserved Site
A, B, C, D	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A, B, C, D	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type	Domain
A, B, C, D	IPR001202	WW domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q13526	breast carcinoma ovarian cancer Severe Recalcitrant Nodular Acne atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma medulloblastoma pilocytic astrocytoma acute promyelocytic leukemia breast cancer malignant ependymoma primitive neuroectodermal tumor astrocytic tumor malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.