| A | Csx12 | e5b2oA1 | A: alpha complex topology | X: CRISPR-associated endonuclease Cas9 alpha-helical lobe | H: F. novicida CRISPR-associated endonuclease Cas9 alpha-helical lobe (From Topology) | T: F. novicida CRISPR-associated endonuclease Cas9 alpha-helical lobe | F: Csx12 | ECOD (1.6) |
| A | EUF08429 | e5b2oA4 | A: a+b two layers | X: SSHS domain | H: SSHS domain in CRISPR-associated endonuclease Cas9 (From Topology) | T: SSHS domain in CRISPR-associated endonuclease Cas9 | F: EUF08429 | ECOD (1.6) |
| A | EUF08577 | e5b2oA5 | A: a+b complex topology | X: CRISPR-associated endonuclease Cas9 C-terminal domain (From Topology) | H: CRISPR-associated endonuclease Cas9 C-terminal domain (From Topology) | T: CRISPR-associated endonuclease Cas9 C-terminal domain | F: EUF08577 | ECOD (1.6) |
| A | EUF08586 | e5b2oA6 | A: a+b complex topology | X: CRISPR-associated endonuclease Cas9 wedge domain (From Topology) | H: CRISPR-associated endonuclease Cas9 wedge domain (From Topology) | T: CRISPR-associated endonuclease Cas9 wedge domain | F: EUF08586 | ECOD (1.6) |
| A | cas_csx12 | e5b2oA2 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: cas_csx12 | ECOD (1.6) |
| A | HNH_4_1 | e5b2oA3 | A: few secondary structure elements | X: His-Me finger endonucleases (From Homology) | H: His-Me finger endonucleases | T: His-Me finger endonucleases | F: HNH_4_1 | ECOD (1.6) |
