5B04

Crystal structure of the eukaryotic translation initiation factor 2B from Schizosaccharomyces pombe

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8100680	3000693	SCOP2B (2022-06-29)
B	SCOP2 Family	IF2B-like	8100679	4002100	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	NagB/RpiA/CoA transferase-like	8100680	3000693	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01008	e5b04A2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
A	PF01008	e5b04A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
B	PF01008	e5b04B1	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
B	PF01008	e5b04B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
D	PF01008	e5b04D2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
D	PF01008	e5b04D1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
C	PF01008	e5b04C2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
C	PF01008	e5b04C1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
E	F_UNCLASSIFIED	e5b04E2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00483	e5b04E1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF00483	ECOD (1.6)
F	F_UNCLASSIFIED	e5b04F2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF00483	e5b04F1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF00483	ECOD (1.6)
G	PF01008	e5b04G2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
G	PF01008	e5b04G1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
H	PF01008	e5b04H2	A: alpha bundles	X: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	H: Translation initiation factor eIF-2B delta subunit N-terminal helical domain (From Topology)	T: Translation initiation factor eIF-2B delta subunit N-terminal helical domain	F: PF01008	ECOD (1.6)
H	PF01008	e5b04H1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01008	ECOD (1.6)
I	PF00132	e5b04I2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
I	PF00483	e5b04I1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF00483	ECOD (1.6)
J	PF00132	e5b04J2	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
J	PF00483	e5b04J1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF00483	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family
C, D	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family
G, H	PF01008	Initiation factor 2 subunit family (IF-2B)	Initiation factor 2 subunit family	-	Family
I, J	PF00483	Nucleotidyl transferase (NTP_transferase)	Nucleotidyl transferase	-	Family
I, J	PF00132	Bacterial transferase hexapeptide (six repeats) (Hexapep)	Bacterial transferase hexapeptide (six repeats)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Translation initiation factor eIF-2B subunit alpha	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process cytoplasmic translation cytoplasmic translational initiation cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of TORC1 signaling regulation of intracellular signal transduction negative regulation of TOR signaling negative regulation of cellular process signal transduction regulation of TORC1 signaling TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 2B complex
C, D	Probable translation initiation factor eIF-2B subunit beta	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process cytoplasmic translation cytoplasmic translational initiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 2B complex
E, F	Probable translation initiation factor eIF-2B subunit gamma	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process cellular process translational initiation protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 2B complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex
G, H	Probable translation initiation factor eIF-2B subunit delta	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process cellular process translational initiation protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 2B complex
I, J	Probable translation initiation factor eIF-2B subunit epsilon	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation cytoplasmic translational initiation metabolic process cellular process translational initiation protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 2B complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
A, B	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
A, B	IPR042528	Translation initiation factor eIF-2B subunit alpha, N-terminal	Homologous Superfamily
A, B	IPR000649	Initiation factor 2B-related	Family
C, D	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
C, D	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
C, D	IPR000649	Initiation factor 2B-related	Family
C, D	IPR027363	Methylthioribose-1-phosphate isomerase, N-terminal	Homologous Superfamily
E, F	IPR005835	Nucleotidyl transferase domain	Domain
E, F	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
G, H	IPR042529	Initiation factor 2B-like, C-terminal	Homologous Superfamily
G, H	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
G, H	IPR000649	Initiation factor 2B-related	Family
I, J	IPR044123	Translation initiation factor eIF-2B subunit epsilon, W2 domain	Domain
I, J	IPR016024	Armadillo-type fold	Homologous Superfamily
I, J	IPR003307	W2 domain	Domain
I, J	IPR001451	Hexapeptide repeat	Repeat
I, J	IPR035543	Translation initiation factor eIF-2B subunit epsilon, N-terminal	Domain
I, J	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
I, J	IPR005835	Nucleotidyl transferase domain	Domain
I, J	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily