Annotations: 5ANC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Translational proteins	8098636	3000811	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	50S Ribosomal protein L14-like	8072064	3000433	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ribosomal protein L16p/L10e	8099536	3000884	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Zn-binding ribosomal proteins	8101525	3001320	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00347	e5ancB1	A: a+b two layers	X: Ribosomal protein L6 (From Topology)	H: Ribosomal protein L6 (From Topology)	T: Ribosomal protein L6	F: PF00347	ECOD (1.6)
C	PF00466	e5ancC2	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal protein L10-like (From Topology)	T: Ribosomal protein L10-like	F: PF00466	ECOD (1.6)
C	PF17777	e5ancC1	A: a+b two layers	X: Insertion domain in 60S ribosomal protein rpP0 (L10P) (From Topology)	H: Insertion domain in 60S ribosomal protein rpP0 (L10P) (From Topology)	T: Insertion domain in 60S ribosomal protein rpP0 (L10P)	F: PF17777	ECOD (1.6)
D	PF00298	e5ancD2	A: alpha arrays	X: HTH	H: HTH	T: Ribosomal protein L11, C-terminal domain	F: PF00298	ECOD (1.6)
D	PF03946	e5ancD1	A: a+b two layers	X: Ribosomal protein L11/L12e N-terminal domain-like	H: Ribosomal protein L11/L12e N-terminal domain (From Topology)	T: Ribosomal protein L11/L12e N-terminal domain	F: PF03946	ECOD (1.6)
G	PF01246	e5ancG1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01246	ECOD (1.6)
I [auth J]	PF09377	e5ancJ1	A: alpha arrays	X: RuvA-C	H: Hypothetical protein AF0491, middle domain (From Topology)	T: Hypothetical protein AF0491, middle domain	F: PF09377	ECOD (1.6)
I [auth J]	PF01172	e5ancJ3	A: a+b two layers	X: FYSH domain (From Topology)	H: FYSH domain (From Topology)	T: FYSH domain	F: PF01172	ECOD (1.6)
I [auth J]	PF20268	e5ancJ2	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF20268	ECOD (1.6)
J [auth K]	F_UNCLASSIFIED	e5ancK5	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth K]	F_UNCLASSIFIED	e5ancK3	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth K]	PF00679	e5ancK1	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF00679	ECOD (1.6)
J [auth K]	PF14492	e5ancK2	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF14492	ECOD (1.6)
J [auth K]	PF00009	e5ancK4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00009	ECOD (1.6)
A	PF00297	e5ancA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00297	ECOD (1.6)
E	PF00238	e5ancE1	A: beta barrels	X: Ribosomal protein L14-like	H: Ribosomal protein L14-related (From Topology)	T: Ribosomal protein L14-related	F: PF00238	ECOD (1.6)
F	PF00252	e5ancF1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal protein L10e	F: PF00252	ECOD (1.6)
H	PF01020	e5ancH1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01020	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00347	Ribosomal protein L6 (Ribosomal_L6)	Ribosomal protein L6	-	Domain
C	PF17777	Insertion domain in 60S ribosomal protein L10P (RL10P_insert)	Insertion domain in 60S ribosomal protein L10P	This domain is found in prokaryotic and archaeal ribosomal L10 protein [1].	Domain
C	PF00466	Ribosomal protein L10 (Ribosomal_L10)	Ribosomal protein L10	-	Family
D	PF03946	Ribosomal protein L11, N-terminal domain (Ribosomal_L11_N)	Ribosomal protein L11, N-terminal domain	The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.	Domain
D	PF00298	Ribosomal protein L11, RNA binding domain (Ribosomal_L11)	Ribosomal protein L11, RNA binding domain	-	Domain
G	PF01246	Ribosomal protein L24e (Ribosomal_L24e)	Ribosomal protein L24e	-	Domain
I [auth J]	PF09377	SBDS protein, domain II (SBDS_domain_II)	SBDS protein, domain II	Members containing this domain are highly conserved in species ranging from archaea to vertebrates and plants [1], including several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autoso ...	Members containing this domain are highly conserved in species ranging from archaea to vertebrates and plants [1], including several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. These proteins play a role in RNA metabolism [2,3]. In yeast Sdo1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes [4]. SBDS protein is composed of three domains. The N-terminal (Pfam:PF01172) (FYSH) domain (domain I) is the most frequent target for disease mutations and contains a novel mixed alpha/beta-fold, the central domain (domain II) represented in this entry consists of a three-helical bundle and the C-terminal domain that has a ferredoxin-like fold [3,5].	Domain
I [auth J]	PF01172	Shwachman-Bodian-Diamond syndrome (SBDS) protein (SBDS)	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	Family
I [auth J]	PF20268	SBDS protein, C-terminal domain (SBDS_C)	SBDS protein, C-terminal domain	Members containing this domain are highly conserved in species ranging from archaea to vertebrates and plants [1], including several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autoso ...	Members containing this domain are highly conserved in species ranging from archaea to vertebrates and plants [1], including several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. These proteins play a role in RNA metabolism [2,3]. In yeast Sdo1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes [4]. The SBDS protein is composed of three domains. The N-terminal (Pfam:PF01172) (FYSH) domain (domain I) is the most frequent target for disease mutations and contains a novel mixed alpha/beta-fold, the central domain (domain II, Pfam:PF09377) consists of a three-helical bundle and this C-terminal domain which has a ferredoxin-like fold [3,5].	Domain
J [auth K]	PF00679	Elongation factor G C-terminus (EFG_C)	Elongation factor G C-terminus	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.	Domain
J [auth K]	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
J [auth K]	PF14492	Elongation Factor G, domain III (EFG_III)	Elongation Factor G, domain III	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679). Structural studies in drosophila indicate this is domain 3 [1].	Domain
A	PF00297	Ribosomal protein L3 (Ribosomal_L3)	Ribosomal protein L3	-	Family
E	PF00238	Ribosomal protein L14p/L23e (Ribosomal_L14)	Ribosomal protein L14p/L23e	-	Domain
F	PF00252	Ribosomal protein L16p/L10e (Ribosomal_L16)	Ribosomal protein L16p/L10e	-	Domain
H	PF01020	Ribosomal L40e family (Ribosomal_L40e)	Ribosomal L40e family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	60S RIBOSOMAL PROTEIN L9	structural molecule activity structural constituent of ribosome RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle protein-containing complex ribosomal subunit membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endocytic vesicle protein-containing complex ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytosol large ribosomal subunit non-membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure
C	60S ACIDIC RIBOSOMAL PROTEIN P0	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding large ribosomal subunit rRNA binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis	lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle cytoplasm vesicle lipid droplet intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle cytoplasm vesicle endocytic vesicle protein-containing complex ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome ribonucleoprotein complex ribosome cytosol large ribosomal subunit cell periphery extracellular matrix external encapsulating structure
D	60S RIBOSOMAL PROTEIN L12	structural molecule activity structural constituent of ribosome RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding large ribosomal subunit rRNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
G	60S RIBOSOMAL PROTEIN L24	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cytoplasmic translation metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
I [auth J]	RIBOSOME MATURATION PROTEIN SBDS	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding cytoskeletal protein binding microtubule binding protein binding tubulin binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development ribonucleoprotein complex biogenesis organelle assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development ribonucleoprotein complex biogenesis organelle assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis organelle organization cellular component assembly cytosolic ribosome assembly cellular process cellular component organization or biogenesis ribosome assembly cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process nucleic acid catabolic process metabolic process macromolecule metabolic process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching blastocyst growth blastocyst development immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development immune system process bone development system development microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization mitotic cell cycle process microtubule-based process cell cycle cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process cellular developmental process hemopoiesis cell differentiation cell development hematopoietic progenitor cell differentiation cell chemotaxis cellular response to stimulus chemotaxis response to stimulus response to external stimulus leukocyte migration cellular response to chemical stimulus taxis response to chemical cell migration cell motility leukocyte chemotaxis locomotion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoskeleton spindle spindle pole microtubule cytoskeleton cytoplasm cytosol nucleoplasm
J [auth K]	ELONGATION FACTOR TU GTP-BINDING DOMAIN-CONTAINING PROTEIN 1	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding translation elongation factor activity nucleic acid binding translation factor activity, RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding translation elongation factor activity nucleic acid binding translation factor activity, RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	ribonucleoprotein complex biogenesis organelle assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis organelle organization cellular component assembly cytosolic ribosome assembly cellular process cellular component organization or biogenesis ribosome assembly ribose phosphate metabolic process GTP metabolic process ribonucleoprotein complex biogenesis organelle assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component organization ribosome biogenesis organelle organization cellular component assembly cytosolic ribosome assembly cellular process cellular component organization or biogenesis ribosome assembly ribose phosphate metabolic process GTP metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex ribonucleoprotein complex
K [auth N]	26S RIBOSOMAL RNA	-	-	-
A	60S RIBOSOMAL PROTEIN L3	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure
E	60S RIBOSOMAL PROTEIN L23	structural molecule activity structural constituent of ribosome RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding large ribosomal subunit rRNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure
F	60S RIBOSOMAL PROTEIN L10	structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle lipid droplet
H	UBIQUITIN-60S RIBOSOMAL PROTEIN L40	protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding structural molecule activity structural constituent of ribosome	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process translation gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process cellular process	protein-containing complex intracellular anatomical structure cellular anatomical entity ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome large ribosomal subunit non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus protein-containing complex intracellular anatomical structure cellular anatomical entity ribosomal subunit intracellular organelle organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome large ribosomal subunit non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR020040	Large ribosomal subunit protein uL6, alpha-beta domain	Domain
B	IPR002359	Large ribosomal subunit protein uL6, conserved site-2	Conserved Site
B	IPR036789	Large ribosomal subunit protein uL6-like, alpha-beta domain superfamily	Homologous Superfamily
B	IPR000702	Large ribosomal subunit protein uL6-like	Family
C	IPR043141	Large ribosomal subunit protein uL10-like domain superfamily	Homologous Superfamily
C	IPR001790	Large ribosomal subunit protein uL10	Family
C	IPR043164	Large ribosomal subunit protein uL10-like, insertion domain superfamily	Homologous Superfamily
C	IPR030670	Large ribosomal subunit protein uL10, eukaryotes	Family
C	IPR040637	Large ribosomal subunit protein uL10-like, insertion domain	Domain
D	IPR020783	Large ribosomal subunit protein uL11, C-terminal	Domain
D	IPR000911	Ribosomal protein uL11	Family
D	IPR036769	Large ribosomal subunit protein uL11, C-terminal domain superfamily	Homologous Superfamily
D	IPR020784	Large ribosomal subunit protein uL11, N-terminal	Domain
D	IPR036796	Large ribosomal subunit protein uL11, N-terminal domain superfamily	Homologous Superfamily
G	IPR000988	Large ribosomal subunit protein eL24-related	Family
G	IPR023442	Large ribosomal subunit protein eL24, conserved site	Conserved Site
G	IPR038630	Ribosomal protein L24e/L24 superfamily	Homologous Superfamily
I [auth J]	IPR018978	Ribosome maturation protein SDO1/SBDS, central domain	Domain
I [auth J]	IPR039100	Ribosome maturation protein Sdo1/SBDS-like	Family
I [auth J]	IPR036786	Ribosome maturation protein SBDS, N-terminal domain superfamily	Homologous Superfamily
I [auth J]	IPR002140	Ribosome maturation protein Sdo1/SBDS	Family
I [auth J]	IPR037188	Ribosome maturation protein Sdo1/SBDS, central domain superfamily	Homologous Superfamily
I [auth J]	IPR018023	Ribosome maturation protein SBDS, conserved site	Conserved Site
I [auth J]	IPR046928	Ribosome maturation protein SDO1/SBDS, C-terminal domain	Domain
I [auth J]	IPR019783	Ribosome maturation protein SDO1/SBDS, N-terminal	Domain
J [auth K]	IPR000795	Translational (tr)-type GTP-binding domain	Domain
J [auth K]	IPR000640	Elongation factor EFG, domain V-like	Domain
J [auth K]	IPR035647	EF-G domain III/V-like	Homologous Superfamily
J [auth K]	IPR041095	Elongation Factor G, domain II	Domain
J [auth K]	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
J [auth K]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
J [auth K]	IPR005225	Small GTP-binding protein domain	Domain
J [auth K]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
J [auth K]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
A	IPR019926	Large ribosomal subunit protein uL3, conserved site	Conserved Site
A	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
A	IPR045077	Large ribosomal subunit protein uL3, archaeal/eukaryotic-type	Family
A	IPR044892	Ribosomal protein L3, domain 3, archaeal-type superfamily	Homologous Superfamily
A	IPR000597	Large ribosomal subunit protein uL3	Family
E	IPR036853	Large ribosomal subunit protein uL14 superfamily	Homologous Superfamily
E	IPR000218	Large ribosomal subunit protein uL14	Family
F	IPR036920	Large ribosomal subunit protein uL16 superfamily	Homologous Superfamily
F	IPR001197	Large ribosomal subunit protein uL16, eukaryotes/archaea	Family
F	IPR016180	Large ribosomal subunit protein uL16 domain	Domain
F	IPR047873	Large ribosomal subunit protein uL16	Family
F	IPR018255	Large ribosomal subunit protein uL16, conserved site, eukaryotes/archaea	Conserved Site
H	IPR019954	Ubiquitin conserved site	Conserved Site
H	IPR038587	Large ribosomal subunit protein eL40 superfamily	Homologous Superfamily
H	IPR000626	Ubiquitin-like domain	Domain
H	IPR019956	Ubiquitin domain	Domain
H	IPR001975	Large ribosomal subunit protein eL40 domain	Domain
H	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
H	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
I [auth J]	Pharos: Q9Y3A5	Shwachman-Diamond syndrome acute myeloid leukemia aplastic anemia idiopathic aplastic anemia Shwachman-Diamond syndrome 1 congenital anemia hematopoietic and lymphoid system neoplasm intellectual disability Shwachman syndrome lung adenocarcinoma exocrine pancreatic insufficiency myelodysplastic syndrome
J [auth K]	Pharos: Q7Z2Z2	lung cancer Shwachman syndrome medulloblastoma Shwachman-Diamond syndrome pancreatic intraductal papillary-mucinous carcinoma Shwachman-Diamond syndrome 2