Annotations: 5AHO

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lactamase_B_6_1	e5ahoA1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_6_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
A	3.40.50.12650	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07522	DNA repair metallo-beta-lactamase (DRMBL)	DNA repair metallo-beta-lactamase	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fift ...	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	5' EXONUCLEASE APOLLO	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity beta-lactamase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds protein-containing complex binding nuclease activity hydrolase activity, acting on ester bonds 5'-3' exonuclease activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity beta-lactamase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds protein-containing complex binding nuclease activity hydrolase activity, acting on ester bonds 5'-3' exonuclease activity exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 5'-3' DNA exonuclease activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding	telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process metabolic process telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus cellular response to stress response to stress protection from non-homologous end joining at telomere telomere capping DNA damage response interstrand cross-link repair DNA repair telomere maintenance via telomere lengthening telomeric 3' overhang formation DNA strand elongation double-strand break repair double-strand break repair via nonhomologous end joining	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A	IPR011084	DNA repair metallo-beta-lactamase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9H816	dyskeratosis congenita type 1 diabetes mellitus breast carcinoma exocrine pancreatic carcinoma Hashimoto thyroiditis hypothyroidism medulloblastoma osteosarcoma systemic lupus erythematosus ulcerative colitis Crohn disease gastric carcinoma heart disease large cell medulloblastoma myocardial infarction dyskeratosis congenita type 1 diabetes mellitus breast carcinoma exocrine pancreatic carcinoma Hashimoto thyroiditis hypothyroidism medulloblastoma osteosarcoma systemic lupus erythematosus ulcerative colitis Crohn disease gastric carcinoma heart disease large cell medulloblastoma myocardial infarction rheumatoid arthritis systemic sclerosis vitiligo Graves disease Hoyeraal-Hreidarsson syndrome malignant pancreatic neoplasm myositis skin basal cell carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.