5A50

The crystal structure of Arabidopsis thaliana CAR4 in complex with two calcium ions, Zn and Phopho Choline

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C2_1	e5a50A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_1	ECOD (1.6)
B	C2_1	e5a50B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: C2_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00168	C2 domain (C2)	C2 domain	-	Domain
B	PF00168	C2 domain (C2)	C2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AT3G17980	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity phospholipid binding	cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone regulation of cellular response to alcohol cellular response to organic substance signal transduction positive regulation of cellular process cellular response to hormone stimulus cellular response to abscisic acid stimulus regulation of biological process regulation of signaling regulation of response to alcohol response to abscisic acid response to alcohol response to endogenous stimulus biological regulation positive regulation of abscisic acid-activated signaling pathway response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol regulation of response to stimulus response to chemical cellular response to lipid regulation of cell communication cellular process regulation of abscisic acid-activated signaling pathway positive regulation of signaling regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to biotic stimulus defense response to bacterium positive regulation of defense response to bacterium positive regulation of response to external stimulus regulation of response to stress response to stress response to bacterium response to external biotic stimulus regulation of defense response to bacterium defense response response to other organism response to external stimulus defense response to other organism positive regulation of defense response response to osmotic stress positive regulation of response to salt stress response to salt stress regulation of response to osmotic stress regulation of response to salt stress response to abiotic stimulus positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	AT3G17980	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity phospholipid binding	cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus cellular response to stimulus positive regulation of cell communication response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid abscisic acid-activated signaling pathway signaling positive regulation of biological process regulation of signal transduction hormone-mediated signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone regulation of cellular response to alcohol cellular response to organic substance signal transduction positive regulation of cellular process cellular response to hormone stimulus cellular response to abscisic acid stimulus regulation of biological process regulation of signaling regulation of response to alcohol response to abscisic acid response to alcohol response to endogenous stimulus biological regulation positive regulation of abscisic acid-activated signaling pathway response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol regulation of response to stimulus response to chemical cellular response to lipid regulation of cell communication cellular process regulation of abscisic acid-activated signaling pathway positive regulation of signaling regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to biotic stimulus defense response to bacterium positive regulation of defense response to bacterium positive regulation of response to external stimulus regulation of response to stress response to stress response to bacterium response to external biotic stimulus regulation of defense response to bacterium defense response response to other organism response to external stimulus defense response to other organism positive regulation of defense response response to osmotic stress positive regulation of response to salt stress response to salt stress regulation of response to osmotic stress regulation of response to salt stress response to abiotic stimulus positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000008	C2 domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR044562	Protein C2-DOMAIN ABA-RELATED	Family
B	IPR000008	C2 domain	Domain
B	IPR035892	C2 domain superfamily	Homologous Superfamily
B	IPR044562	Protein C2-DOMAIN ABA-RELATED	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				C2 domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.