Annotations: 5A2F

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5a2fA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF08205	e5a2fA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08205	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD166 ANTIGEN	protein binding binding signaling receptor binding identical protein binding	response to stimulus immune response immune system process adaptive immune response axon extension multicellular organismal process axonogenesis cellular developmental process cell projection organization developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis response to stimulus immune response immune system process adaptive immune response axon extension multicellular organismal process axonogenesis cellular developmental process cell projection organization developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cell growth cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development axon extension involved in axon guidance cellular component organization or biogenesis neuron projection extension involved in neuron projection guidance system development developmental process neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process retinal ganglion cell axon guidance motor neuron axon guidance heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation signal transduction cell communication	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection immunological synapse cell body neuronal cell body axon

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR013106	Immunoglobulin V-set domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013162	CD80-like, immunoglobulin C2-set	Domain
A	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13740	Mammary Neoplasms, Experimental sarcomatoid carcinoma carcinoma oligodendroglioma progressive supranuclear palsy ulcerative colitis breast cancer Crohn disease ductal breast carcinoma in situ interstitial cystitis lung cancer medulloblastoma ovarian cancer psoriasis sinusitis Mammary Neoplasms, Experimental sarcomatoid carcinoma carcinoma oligodendroglioma progressive supranuclear palsy ulcerative colitis breast cancer Crohn disease ductal breast carcinoma in situ interstitial cystitis lung cancer medulloblastoma ovarian cancer psoriasis sinusitis undifferentiated carcinoma cutaneous lupus erythematosus esophageal adenocarcinoma invasive ductal breast carcinoma malignant colon neoplasm mammary neoplasms, animal nasopharyngeal carcinoma pilocytic astrocytoma rheumatoid arthritis tuberculosis astrocytic tumor cystic fibrosis glioblastoma large cell medulloblastoma malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.