Annotations: 5A1W

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8089854	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8089854	3002022	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	SNARE-like	8082715	3001113	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00025	e5a1wA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
B	PF00025	e5a1wB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
C	PF00400	e5a1wC3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
C	PF04053	e5a1wC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF04053	ECOD (1.6)
C	PF04053	e5a1wC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04053	ECOD (1.6)
D	PF00400	e5a1wD3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
D	PF04053	e5a1wD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF04053	ECOD (1.6)
D	PF04053	e5a1wD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04053	ECOD (1.6)
E	PF01602	e5a1wE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
F	PF01217	e5a1wF1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)
G	PF07718	e5a1wG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07718	ECOD (1.6)
G	PF01602	e5a1wG4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01602	ECOD (1.6)
G	PF14806	e5a1wG3	A: a+b two layers	X: TBP-like	H: Subdomain of clathrin and coatomer appendage domain (From Topology)	T: Subdomain of clathrin and coatomer appendage domain	F: PF14806	ECOD (1.6)
H	PF00928	e5a1wH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF00928	ECOD (1.6)
H	PF01217	e5a1wH3	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF01217	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00025	ADP-ribosylation factor family (Arf)	ADP-ribosylation factor family	Pfam combines a number of different Prosite families together	Domain
C	PF04053	Coatomer WD associated region (Coatomer_WDAD)	Coatomer WD associated region	-	Repeat
C	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
D	PF04053	Coatomer WD associated region (Coatomer_WDAD)	Coatomer WD associated region	-	Repeat
D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
E	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
F	PF01217	Clathrin adaptor complex small chain (Clat_adaptor_s)	Clathrin adaptor complex small chain	-	Domain
G	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
G	PF14806	Coatomer beta subunit appendage platform (Coatomer_b_Cpla)	Coatomer beta subunit appendage platform	This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ADP-RIBOSYLATION FACTOR 1	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism Golgi to plasma membrane transport post-Golgi vesicle-mediated transport localization within membrane vesicle-mediated transport vesicle-mediated transport to the plasma membrane Golgi vesicle transport endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytosol cell periphery plasma membrane membrane
C	COATOMER SUBUNIT ALPHA	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding hormone activity protein binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity structural molecule activity	protein localization localization cellular localization protein localization to cell leading edge cellular macromolecule localization macromolecule localization cellular process protein localization to axon transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport protein localization localization cellular localization protein localization to cell leading edge cellular macromolecule localization macromolecule localization cellular process protein localization to axon transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport establishment of protein localization nitrogen compound transport organic substance transport protein transport intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum multicellular organismal process regulation of body fluid levels system process secretion by tissue pancreatic juice secretion digestive system process secretion biological regulation body fluid secretion digestion regulation of biological quality	membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle Golgi-associated vesicle vesicle COPI vesicle coat Golgi apparatus membrane cellular anatomical entity coated membrane intracellular membrane-bounded organelle COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane organelle Golgi-associated vesicle membrane cytoplasm organelle membrane growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection site of polarized growth Golgi membrane somatodendritic compartment cell body neuronal cell body extracellular region extracellular space
D	COATOMER SUBUNIT BETA'	protein binding binding kinase binding protein kinase C binding enzyme binding protein kinase binding structural molecule activity	localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex vesicle coat intracellular vesicle membrane protein complex COPI-coated vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex vesicle coat intracellular vesicle membrane protein complex COPI-coated vesicle membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle Golgi-associated vesicle vesicle COPI vesicle coat membrane coated membrane COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane Golgi membrane cytosol
E	COATOMER SUBUNIT GAMMA-1	structural molecule activity	localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi localization establishment of organelle localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell protein localization localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi localization establishment of organelle localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell protein localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport secretion establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell endoplasmic reticulum to Golgi vesicle-mediated transport organelle transport along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex vesicle coat intracellular vesicle membrane protein complex COPI-coated vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex vesicle coat intracellular vesicle membrane protein complex COPI-coated vesicle membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle Golgi-associated vesicle vesicle COPI vesicle coat membrane coated membrane COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane Golgi membrane cytosol endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum
F	COATOMER SUBUNIT ZETA-1	-	localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle Golgi-associated vesicle vesicle COPI vesicle coat Golgi apparatus membrane cellular anatomical entity coated membrane intracellular membrane-bounded organelle COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane organelle Golgi-associated vesicle membrane cytoplasm organelle membrane Golgi membrane
G	COATOMER SUBUNIT BETA	structural molecule activity	localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle Golgi apparatus membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle Golgi apparatus endomembrane system protein-containing complex vesicle coat membrane protein complex membrane coat bounding membrane of organelle vesicle membrane COPI vesicle coat membrane coated membrane COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane Golgi membrane cytosol cell periphery plasma membrane endoplasmic reticulum-Golgi intermediate compartment
H	COATOMER SUBUNIT DELTA	-	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior Golgi localization organelle localization localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport adult locomotory behavior behavior multicellular organismal process adult behavior locomotory behavior Golgi localization organelle localization protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization pigmentation developmental process head development cerebellar cortex maturation hindbrain maturation central nervous system maturation cerebellum maturation animal organ development brain development cerebellar Purkinje cell layer maturation nervous system development developmental maturation cerebellar cortex development multicellular organism development cerebellar Purkinje cell layer development cerebellum development central nervous system development anatomical structure maturation metencephalon development anatomical structure development hindbrain development system development establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle Golgi apparatus membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle COPI-coated vesicle intracellular organelle cytoplasmic vesicle organelle coated vesicle cytoplasm Golgi-associated vesicle vesicle Golgi apparatus endomembrane system protein-containing complex vesicle coat membrane protein complex membrane coat bounding membrane of organelle vesicle membrane COPI vesicle coat membrane coated membrane COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane Golgi membrane endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR045872	ADP-ribosylation factor 1-5	Family
A, B	IPR005225	Small GTP-binding protein domain	Domain
A, B	IPR006689	Small GTPase superfamily, ARF/SAR type	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR019775	WD40 repeat, conserved site	Conserved Site
C	IPR016391	Coatomer subunit alpha	Family
C	IPR010714	Coatomer, alpha subunit, C-terminal	Domain
C	IPR047312	Coatomer subunit alpha, WD Associated Region	Domain
C	IPR011048	Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily	Homologous Superfamily
C	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
C	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C	IPR006692	Coatomer, WD associated region	Domain
C	IPR001680	WD40 repeat	Repeat
C	IPR020472	G-protein beta WD-40 repeat	Repeat
D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
D	IPR016453	Coatomer beta' subunit (COPB2)	Family
D	IPR006692	Coatomer, WD associated region	Domain
D	IPR001680	WD40 repeat	Repeat
D	IPR020472	G-protein beta WD-40 repeat	Repeat
D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
E	IPR016024	Armadillo-type fold	Homologous Superfamily
E	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
E	IPR013040	Coatomer, gamma subunit, appendage, Ig-like subdomain	Domain
E	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
E	IPR011989	Armadillo-like helical	Homologous Superfamily
E	IPR032154	Coatomer subunit gamma, C-terminal	Domain
E	IPR017106	Coatomer gamma subunit	Family
E	IPR037067	Coatomer, gamma subunit, appendage domain superfamily	Homologous Superfamily
E	IPR012295	TBP domain superfamily	Homologous Superfamily
E	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain	Homologous Superfamily
F	IPR000804	Clathrin adaptor complex, small chain	Conserved Site
F	IPR022775	AP complex, mu/sigma subunit	Domain
F	IPR039652	Coatomer subunit zeta	Family
F	IPR011012	Longin-like domain superfamily	Homologous Superfamily
G	IPR016460	Coatomer beta subunit (COPB1)	Family
G	IPR016024	Armadillo-type fold	Homologous Superfamily
G	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
G	IPR011710	Coatomer beta subunit, C-terminal	Domain
G	IPR029446	Coatomer beta subunit, appendage platform domain	Domain
G	IPR011989	Armadillo-like helical	Homologous Superfamily
H	IPR011012	Longin-like domain superfamily	Homologous Superfamily
H	IPR027059	Coatomer delta subunit	Family
H	IPR022775	AP complex, mu/sigma subunit	Domain
H	IPR036168	AP-2 complex subunit mu, C-terminal superfamily	Homologous Superfamily
H	IPR028565	Mu homology domain	Domain