4ZQY

Ringhalexin from hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4zqyb_	Small proteins	Snake toxin-like	Snake toxin-like	automated matches	automated matches	(Hemachatus haemachatus ) [TaxId: 8626 ],	SCOPe (2.08)
C	d4zqyc_	Small proteins	Snake toxin-like	Snake toxin-like	automated matches	automated matches	(Hemachatus haemachatus ) [TaxId: 8626 ],	SCOPe (2.08)
A	d4zqya_	Small proteins	Snake toxin-like	Snake toxin-like	automated matches	automated matches	(Hemachatus haemachatus ) [TaxId: 8626 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Snake toxin-like	8059553	3000545	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Snake toxin-like	8059553	3000545	SCOP2B (2022-06-29)
A	SCOP2 Family	Snake venom toxins	8059552	4003278	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Snake toxin-like	8059553	3000545	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Toxin_TOLIP	e4zqyB1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
C	Toxin_TOLIP	e4zqyC1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
A	Toxin_TOLIP	e4zqyA1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
C	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
A	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00087	Snake toxin and toxin-like protein (Toxin_TOLIP)	Snake toxin and toxin-like protein	This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short ...	This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Ringhalexin	toxin activity	envenomation resulting in modulation of process in another organism envenomation resulting in modulation of blood coagulation in another organism biological process involved in interspecies interaction between organisms envenomation resulting in negative regulation of blood coagulation in another organism envenomation resulting in impairment of hemostasis in another organism modulation of process of another organism	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR018354	Snake toxin, conserved site	Conserved Site
A, B, C	IPR035076	Snake toxin/toxin-like	Domain
A, B, C	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
A, B, C	IPR003571	Snake three-finger toxin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.