4ZJM

Crystal Structure of Mycobacterium tuberculosis LpqH (Rv3763)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	LpqH-like	8047266	4005537	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	LpqH-like	8093056	3002669	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	LpqH-like	8093056	3002669	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF05481	e4zjmC1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
A	PF05481	e4zjmA1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
B	PF05481	e4zjmB1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
D	PF05481	e4zjmD1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
E	PF05481	e4zjmE1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
F	PF05481	e4zjmF1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)
G	PF05481	e4zjmG1	A: beta barrels	X: Lipocalins/Streptavidin	H: LpqH (From Topology)	T: LpqH	F: PF05481	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
A	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
B	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
D	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
E	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
F	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family
G	PF05481	Mycobacterium 19 kDa lipoprotein antigen (Myco_19_kDa)	Mycobacterium 19 kDa lipoprotein antigen	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
A	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
B	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
D	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
E	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
F	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region
G	Lipoprotein LpqH	host cell surface binding binding host cell surface receptor binding	symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction modulation by symbiont of host process response to host immune response response to host response to external biotic stimulus modulation of process of another organism defense response defense response to bacterium defense response to other organism response to stress response to bacterium	cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle external encapsulating structure cell wall peptidoglycan-based cell wall host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR008691	19kDa lipoprotein antigen	Family
A	IPR008691	19kDa lipoprotein antigen	Family
B	IPR008691	19kDa lipoprotein antigen	Family
D	IPR008691	19kDa lipoprotein antigen	Family
E	IPR008691	19kDa lipoprotein antigen	Family
F	IPR008691	19kDa lipoprotein antigen	Family
G	IPR008691	19kDa lipoprotein antigen	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084
A	MLY	Parent Component: LYS RESID: AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
B	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
D	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
E	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
F	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084
G	MLY	Parent Component: LYS RESID: AA0075 , AA0075 , AA0075 , AA0075 , AA0075 , AA0075 , AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084 , N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.