Annotations: 4ZGN

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07065	e4zgnA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: PF07065	ECOD (1.6)
B	PF09173	e4zgnB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Aminomethyltransferase beta-barrel domain	F: PF09173	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07065	D123 (D123)	D123	-	Family
B	PF09173	Initiation factor eIF2 gamma, C terminal (eIF2_C)	Initiation factor eIF2 gamma, C terminal	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cell division cycle protein 123	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein folding chaperone	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis eukaryotic translation initiation factor 2 complex assembly	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B	Eukaryotic translation initiation factor 2 subunit gamma	RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding methionyl-initiator methionine tRNA binding translation regulator activity translation regulator activity, nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding guanyl nucleotide binding GTP binding RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding methionyl-initiator methionine tRNA binding translation regulator activity translation regulator activity, nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis formation of translation preinitiation complex protein-containing complex organization cytoplasmic translation cytoplasmic translational initiation regulation of cellular process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of translational fidelity positive regulation of macromolecule metabolic process regulation of biological quality positive regulation of cellular process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process regulation of metabolic process regulation of translational fidelity positive regulation of cellular biosynthetic process	protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity multi-eIF complex cytosol eukaryotic translation initiation factor 2 complex eukaryotic 48S preinitiation complex intracellular organelle organelle intracellular non-membrane-bounded organelle protein-containing complex translation preinitiation complex intracellular anatomical structure eukaryotic 43S preinitiation complex ribonucleoprotein complex cytoplasm cellular anatomical entity multi-eIF complex cytosol eukaryotic translation initiation factor 2 complex eukaryotic 48S preinitiation complex intracellular organelle organelle intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009772	Cell division cycle protein 123	Family
B	IPR000795	Translational (tr)-type GTP-binding domain	Domain
B	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Homologous Superfamily
B	IPR004161	Translation elongation factor EFTu-like, domain 2	Domain
B	IPR044128	Initiation factor eIF2 gamma, GTP-binding domain	Domain
B	IPR015256	Initiation factor eIF2 gamma, C-terminal	Domain
B	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
B	IPR044127	Initiation factor eIF2 gamma, domain 2	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.