4ZDS

Crystal Structure of core DNA binding domain of Arabidopsis Thaliana Transcription Factor Ethylene-Insensitive 3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4zdsa1	All alpha proteins	LEM/SAP HeH motif	DNA-binding domain of EIN3-like	DNA-binding domain of EIN3-like	automated matches	(Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
A	d4zdsa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d4zdsb1	All alpha proteins	LEM/SAP HeH motif	DNA-binding domain of EIN3-like	DNA-binding domain of EIN3-like	automated matches	(Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d4zdsb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNA-binding domain of EIN3-like	8063029	3001801	SCOP2B (2022-06-29)
B	SCOP2 Family	DNA-binding domain of EIN3-like	8063028	4002829	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	DNA-binding domain of EIN3-like	8063029	3001801	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EIN3	e4zdsA1	A: alpha arrays	X: DNA-binding domain of EIN3-like (From Topology)	H: DNA-binding domain of EIN3-like (From Topology)	T: DNA-binding domain of EIN3-like	F: EIN3	ECOD (1.6)
B	EIN3	e4zdsB1	A: alpha arrays	X: DNA-binding domain of EIN3-like (From Topology)	H: DNA-binding domain of EIN3-like (From Topology)	T: DNA-binding domain of EIN3-like	F: EIN3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3180.10	Mainly Alpha	Orthogonal Bundle	DNA-binding domain of ethylene- insensitive3-like3	DNA-binding domain of EIN3-like	CATH (4.3.0)
B	1.10.3180.10	Mainly Alpha	Orthogonal Bundle	DNA-binding domain of ethylene- insensitive3-like3	DNA-binding domain of EIN3-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04873	Ethylene insensitive 3, DNA-binding domain (EIN3_DNA-bd)	Ethylene insensitive 3, DNA-binding domain	Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell gro ...	Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence. This entry represents the DNA-binding domain of EIN3 and EIN3-like proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein ETHYLENE INSENSITIVE 3	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding kinase binding enzyme binding histone binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding protein-containing complex binding DNA binding binding organic cyclic compound binding nucleic acid binding protein binding kinase binding enzyme binding histone binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding transcription regulator activity DNA-binding transcription factor activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular response to stimulus response to organic substance response to stimulus signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus ethylene-activated signaling pathway response to hormone response to ethylene signal transduction cellular response to organic substance cellular response to hormone stimulus phosphorelay signal transduction system cellular response to ethylene stimulus response to endogenous stimulus cellular response to chemical stimulus response to chemical response to oxygen-containing compound cellular response to oxygen-containing compound sugar mediated signaling pathway cellular response to carbohydrate stimulus response to carbohydrate carbohydrate mediated signaling response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus protein-DNA complex organization cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis protein-containing complex organization epigenetic regulation of gene expression monosaccharide metabolic process oxoacid metabolic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process L-ascorbic acid metabolic process cellular ketone metabolic process regulation of small molecule metabolic process lactone biosynthetic process small molecule metabolic process regulation of vitamin metabolic process regulation of carbohydrate metabolic process water-soluble vitamin metabolic process carbohydrate metabolic process water-soluble vitamin biosynthetic process regulation of cellular ketone metabolic process small molecule biosynthetic process regulation of L-ascorbic acid biosynthetic process carbohydrate biosynthetic process carboxylic acid metabolic process monosaccharide biosynthetic process vitamin metabolic process lactone metabolic process regulation of carbohydrate biosynthetic process L-ascorbic acid biosynthetic process biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR047091	Ethylene insensitive 3-like, DNA-binding domain	Domain
A, B	IPR006957	Ethylene insensitive 3	Family
A, B	IPR023278	Ethylene insensitive 3-like protein, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.