Annotations: 4Z79

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4z79a_	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	RNI-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	28-residue LRR	8061613	4003523	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RNI-like	8061614	3000990	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e4z79A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Leiomodin-1 Actin-Binding Site 2 (ABS2)	cytoskeletal protein binding protein binding binding tropomyosin binding actin binding	regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly pointed-end actin filament capping regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly pointed-end actin filament capping regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly regulation of biological process negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular component organization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization cellular component organization or biogenesis regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization biological regulation regulation of actin polymerization or depolymerization regulation of cellular component biogenesis organelle organization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization cellular process negative regulation of actin filament depolymerization protein depolymerization cytoskeleton organization regulation of anatomical structure size positive regulation of organelle organization positive regulation of cellular component organization positive regulation of biological process positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of cellular process positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of actin filament polymerization actin nucleation multicellular organismal process system process muscle contraction muscle system process cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation muscle structure development striated muscle cell development cellular anatomical entity morphogenesis muscle cell development cell differentiation anatomical structure development developmental process actomyosin structure organization organelle assembly anatomical structure morphogenesis myofibril assembly anatomical structure formation involved in morphogenesis striated muscle cell differentiation	membrane cellular anatomical entity intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane cellular anatomical entity intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton cytosol polymeric cytoskeletal fiber actin filament actin cytoskeleton striated muscle thin filament myofilament

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR004934	Tropomodulin	Family
A	IPR003124	WH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P29536	megacystis-microcolon-intestinal hypoperistalsis syndrome 1 endometriosis coronary artery disease pancreatic intraductal papillary-mucinous carcinoma Pick disease subependymal giant cell astrocytoma adrenal cortex carcinoma breast fibroadenoma cystic fibrosis Endometrioma invasive ductal breast carcinoma neuronal intestinal dysplasia pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma breast cancer megacystis-microcolon-intestinal hypoperistalsis syndrome 1 endometriosis coronary artery disease pancreatic intraductal papillary-mucinous carcinoma Pick disease subependymal giant cell astrocytoma adrenal cortex carcinoma breast fibroadenoma cystic fibrosis Endometrioma invasive ductal breast carcinoma neuronal intestinal dysplasia pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma breast cancer ductal breast carcinoma in situ lung adenocarcinoma myocardial infarction non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis breast carcinoma endogenous depression heart disease malignant colon neoplasm myopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.