Annotations: 4Z0V

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PLN03144_like	e4z0vA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PLN03144_like	ECOD (1.6)
A	Exo_endo_phos	e4z0vA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03372	Endonuclease/Exonuclease/phosphatase family (Exo_endo_phos)	Endonuclease/Exonuclease/phosphatase family	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3. ...	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	Domain
A	PF21171	2',5'-phosphodiesterase 12-like, N-terminal domain (PDE12-like_N)	2',5'-phosphodiesterase 12-like, N-terminal domain	This domain is found in 2',5'-phosphodiesterase 12 from humans (PDE12) and similar animal proteins. Pde12 cleaves 2',5'- phosphodiester bond linking adenosines of oligoadenylates. It plays a role as a negative regulator of the 2-5A system that is one ...	This domain is found in 2',5'-phosphodiesterase 12 from humans (PDE12) and similar animal proteins. Pde12 cleaves 2',5'- phosphodiester bond linking adenosines of oligoadenylates. It plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumour functions induced by interferons (IFNs). PDE12 is organised into two clear domains: an N-terminal domain (this entry) and a C-terminal domain (Pfam:PF03372). This domain is primarily composed of extended loop regions around a core composed of a six beta-strand meander that forms a two-layer beta-sandwich, showing an immunoglobulin-like fold [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	2',5'-phosphodiesterase 12	nuclease activity hydrolase activity, acting on ester bonds hydrolase activity exonuclease activity catalytic activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid oligoribonucleotidase activity RNA nuclease activity oligonucleotidase activity 3'-5'-RNA exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters 3'-5' exonuclease activity RNA exonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity exonuclease activity catalytic activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid oligoribonucleotidase activity RNA nuclease activity oligonucleotidase activity 3'-5'-RNA exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters 3'-5' exonuclease activity RNA exonuclease activity poly(A)-specific ribonuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters cation binding ion binding binding metal ion binding small molecule binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of mitochondrial mRNA stability metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process catabolic process cellular biosynthetic process RNA metabolic process macromolecule catabolic process regulation of mRNA catabolic process organic substance metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of mRNA stability regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process cellular response to nitrogen compound cellular response to stimulus response to organic substance cellular response to dsRNA response to stimulus cellular response to organic cyclic compound response to dsRNA response to nitrogen compound cellular response to chemical stimulus response to chemical cellular response to organic substance response to organic cyclic compound biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cellular response to type II interferon response to biotic stimulus response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus immune system process defense response to other organism defense response to virus antiviral innate immune response response to virus positive regulation of viral genome replication positive regulation of viral process positive regulation of biological process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication mitochondrial RNA catabolic process mitochondrial mRNA catabolic process mitochondrial RNA metabolic process mRNA processing RNA processing cellular response to interferon-alpha response to interferon-alpha positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA destabilization RNA destabilization nuclear-transcribed mRNA catabolic process positive regulation of catabolic process positive regulation of mRNA catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005135	Endonuclease/exonuclease/phosphatase	Domain
A	IPR048821	2',5'-phosphodiesterase 12-like, N-terminal domain	Domain
A	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6L8Q7	cardiovirus infectious disease respiratory syncytial virus infectious disease pancreatic intraductal papillary-mucinous neoplasm lung cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.