4YRV

Crystal structure of Anabaena transcription factor HetR complexed with 21-bp DNA from hetP promoter

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	Homeodomain-like	8055698	3000001	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	HetR C-terminal hood domain	8055700	3002297	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8055699	3000034	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Winged helix DNA-binding domain	8055699	3000034	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Homeodomain-like	8055698	3000001	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	HetR C-terminal hood domain	8055700	3002297	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF03574	e4yrvB3	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03574	ECOD (1.6)
A [auth B]	PF03574	e4yrvB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF03574	ECOD (1.6)
A [auth B]	PF18460	e4yrvB2	A: a+b duplicates or obligate multimers	X: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	H: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	T: Dimerization domain of heterocyst differentiation protein HetR	F: PF18460	ECOD (1.6)
B [auth A]	PF03574	e4yrvA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03574	ECOD (1.6)
B [auth A]	PF03574	e4yrvA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF03574	ECOD (1.6)
B [auth A]	PF18460	e4yrvA3	A: a+b duplicates or obligate multimers	X: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	H: Dimerization domain of heterocyst differentiation protein HetR (From Topology)	T: Dimerization domain of heterocyst differentiation protein HetR	F: PF18460	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.10.10.1680	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, N-terminal DNA-binding domain	CATH (4.3.0)
A [auth B]	1.10.10.1670	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, flap domain	CATH (4.3.0)
B [auth A]	1.10.10.1680	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, N-terminal DNA-binding domain	CATH (4.3.0)
B [auth A]	1.10.10.1670	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	HetR, flap domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF03574	Peptidase family S48 (Peptidase_S48)	Peptidase family S48	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Heterocyst differentiation control protein	DNA binding binding organic cyclic compound binding nucleic acid binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding	developmental process heterocyst development cellular developmental process cellular process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-
C	DNA (5'-D(PGPCPGPAPGPGPGPGPTPCPTPAPAPCPCPCPCPTPCPAP*T)-3')	-	-	-
D	DNA (5'-D(PAPTPGPAPGPGPGPGPTPTPAPGPAPCPCPCPCPTPCPGP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR041935	HetR, flap domain	Homologous Superfamily
A [auth B], B [auth A]	IPR041936	HetR, N-terminal DNA-binding domain	Homologous Superfamily
A [auth B], B [auth A]	IPR005319	Peptidase S48, DNA-binding transcriptional activator HetR	Family
A [auth B], B [auth A]	IPR040949	HetR, C-terminal Hood domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.