4YR8

Crystal structure of JNK in complex with a regulator protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G [auth F]	d4yr8f_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth E]	d4yr8e_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth A]	d4yr8a_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d4yr8c_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth G]	d4yr8g_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth B]	d4yr8b_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth D]	d4yr8d_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d4yr8h_	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G [auth F]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8040900	3000066	SCOP2B (2022-06-29)
A [auth E]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8040900	3000066	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8040900	3000066	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8040900	3000066	SCOP2B (2022-06-29)
B [auth G]	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081823	3000304	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081823	3000304	SCOP2B (2022-06-29)
F [auth D]	SCOP2 Family	Dual specificity phosphatase-like	8081822	4000437	SCOP2 (2022-06-29)
F [auth D]	SCOP2 Superfamily	(Phosphotyrosine protein) phosphatases II	8081823	3000304	SCOP2 (2022-06-29)
H	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8081823	3000304	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G [auth F]	PF00069	e4yr8F1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
A [auth E]	PF00069	e4yr8E1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
C [auth A]	PF00069	e4yr8A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
E [auth C]	PF00069	e4yr8C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B [auth G]	PF00782	e4yr8G1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)
D [auth B]	PF00782	e4yr8B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)
F [auth D]	PF00782	e4yr8D1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)
H	PF00782	e4yr8H1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00782	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G [auth F]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
G [auth F]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A [auth E]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A [auth E]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C [auth A]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C [auth A]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
E [auth C]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
E [auth C]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B [auth G]	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
D [auth B]	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
F [auth D]	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
H	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], C [auth A], E [auth C], G [auth F]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B [auth G], D [auth B], F [auth D], H	PF00782	Dual specificity phosphatase, catalytic domain (DSPc)	Dual specificity phosphatase, catalytic domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], C [auth A], E [auth C], G [auth F]	Mitogen-activated protein kinase 8	histone deacetylase binding protein binding binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein phosphatase binding phosphatase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding histone deacetylase binding protein binding binding enzyme binding enzyme regulator activity molecular function regulator activity histone deacetylase regulator activity protein phosphatase binding phosphatase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity JUN kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity MAP kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein serine kinase activity protein serine/threonine kinase binding kinase binding protein kinase binding	regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function regulation of biological process catabolic process regulation of cellular process macroautophagy cellular metabolic process autophagy regulation of cellular metabolic process regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function regulation of biological process catabolic process regulation of cellular process macroautophagy cellular metabolic process autophagy regulation of cellular metabolic process regulation of catabolic process regulation of autophagy cellular catabolic process regulation of macroautophagy regulation of cellular catabolic process metabolic process cellular process regulation of metabolic process process utilizing autophagic mechanism cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cellular biosynthetic process positive regulation of molecular function positive regulation of cyclase activity regulation of catalytic activity positive regulation of catalytic activity regulation of cyclase activity positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death organonitrogen compound metabolic process protein phosphorylation phosphorylation primary metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation cellular response to stimulus cellular response to stress response to stimulus response to stress cellular senescence response to oxidative stress cellular response to chemical stimulus response to chemical cellular response to oxidative stress cellular response to chemical stress regulation of DNA replication origin binding regulation of DNA binding signaling intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade signal transduction response to light stimulus response to radiation response to abiotic stimulus response to UV immune response-regulating cell surface receptor signaling pathway cell surface receptor signaling pathway immune response Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process Fc-epsilon receptor signaling pathway regulation of immune response regulation of immune system process peptidyl-serine modification peptidyl-serine phosphorylation response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation cellular response to inorganic substance cellular response to metal ion response to cadmium ion response to inorganic substance response to metal ion cellular response to cadmium ion positive regulation of protein metabolic process regulation of protein metabolic process regulation of primary metabolic process JUN phosphorylation stress-activated MAPK cascade stress-activated protein kinase signaling cascade rhythmic process circadian rhythm regulation of circadian rhythm negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process response to organic substance biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly regulation of signal transduction cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway regulation of innate immune response positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of cellular component organization positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus regulation of response to stress innate immune response protein-containing complex assembly cellular component organization or biogenesis regulation of signaling positive regulation of innate immune response defense response protein-containing complex organization positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis regulation of cell communication positive regulation of signaling response to mechanical stimulus response to reactive oxygen species cellular response to reactive oxygen species cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of cell killing positive regulation of cell killing cell killing	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol basal dendrite somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection axon membrane-bounded organelle nucleus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol basal dendrite somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection axon membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen synapse cell junction
B [auth G], D [auth B], F [auth D], H	Dual specificity protein phosphatase 16	JUN kinase binding protein binding binding kinase binding enzyme binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein serine/threonine phosphatase activity JUN kinase binding protein binding binding kinase binding enzyme binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein serine/threonine phosphatase activity myosin phosphatase activity mitogen-activated protein kinase p38 binding mitogen-activated protein kinase binding protein tyrosine/threonine phosphatase activity MAP kinase tyrosine phosphatase activity MAP kinase phosphatase activity protein tyrosine phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity protein tyrosine/serine/threonine phosphatase activity	cellular response to stimulus regulation of cellular process response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity cellular response to stimulus regulation of cellular process response to stimulus regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity negative regulation of JNK cascade regulation of phosphate metabolic process JNK cascade phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process signal transduction phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of biological process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of JNK cascade regulation of cellular metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process negative regulation of cell communication organic substance metabolic process regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity negative regulation of cellular process protein metabolic process negative regulation of JUN kinase activity negative regulation of macromolecule metabolic process regulation of signaling organonitrogen compound metabolic process negative regulation of response to stimulus biological regulation negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of signal transduction negative regulation of phosphorus metabolic process regulation of JUN kinase activity MAPK cascade regulation of cell communication regulation of phosphorylation cellular process negative regulation of phosphorylation negative regulation of MAPK cascade protein dephosphorylation dephosphorylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasmic vesicle intracellular vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], C [auth A], E [auth C], G [auth F]	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site	Conserved Site
A [auth E], C [auth A], E [auth C], G [auth F]	IPR000719	Protein kinase domain	Domain
A [auth E], C [auth A], E [auth C], G [auth F]	IPR008351	Mitogen-activated protein (MAP) kinase, JNK	Family
A [auth E], C [auth A], E [auth C], G [auth F]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth E], C [auth A], E [auth C], G [auth F]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B [auth G], D [auth B], F [auth D], H	IPR001763	Rhodanese-like domain	Domain
B [auth G], D [auth B], F [auth D], H	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
B [auth G], D [auth B], F [auth D], H	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
B [auth G], D [auth B], F [auth D], H	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
B [auth G], D [auth B], F [auth D], H	IPR036873	Rhodanese-like domain superfamily	Homologous Superfamily
B [auth G], D [auth B], F [auth D], H	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase	Family
B [auth G], D [auth B], F [auth D], H	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
B [auth G], D [auth B], F [auth D], H	IPR020422	Dual specificity protein phosphatase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E], C [auth A], E [auth C], G [auth F]	Pharos: P45983	acute liver failure Hyperalgesia trigeminal neuralgia extrahepatic cholestasis glioblastoma ischemia reperfusion injury ovarian cancer precancerous condition atopic eczema schizophrenia cancer gastric cancer hereditary diffuse gastric adenocarcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma acute liver failure Hyperalgesia trigeminal neuralgia extrahepatic cholestasis glioblastoma ischemia reperfusion injury ovarian cancer precancerous condition atopic eczema schizophrenia cancer gastric cancer hereditary diffuse gastric adenocarcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma acute myeloid leukemia atypical teratoid rhabdoid tumor depressive disorder thrombocytopenia due to immune destruction tuberculosis gastric neoplasm malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma breast cancer spina bifida dermatitis, atopic
B [auth G], D [auth B], F [auth D], H	Pharos: Q9BY84	Liver Cirrhosis, Experimental acne breast carcinoma pancreatic ductal adenocarcinoma systemic lupus erythematosus ulcerative colitis atypical teratoid rhabdoid tumor inflammatory bowel disease medulloblastoma primitive neuroectodermal tumor transitional cell carcinoma breast cancer interstitial cystitis osteosarcoma spina bifida Liver Cirrhosis, Experimental acne breast carcinoma pancreatic ductal adenocarcinoma systemic lupus erythematosus ulcerative colitis atypical teratoid rhabdoid tumor inflammatory bowel disease medulloblastoma primitive neuroectodermal tumor transitional cell carcinoma breast cancer interstitial cystitis osteosarcoma spina bifida tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.