Annotations: 4YO2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02319	e4yo2A1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF02319	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02319	E2F/DP family winged-helix DNA-binding domain (E2F_TDP)	E2F/DP family winged-helix DNA-binding domain	This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having incre ...	This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription factor E2F8	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding identical protein binding protein binding	regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process cell cycle cell division regulation of cell cycle cell cycle process developmental process placenta development animal organ development anatomical structure development extraembryonic membrane development chorion development cellular developmental process cell differentiation chorionic trophoblast cell differentiation multicellular organismal process blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development cell differentiation involved in embryonic placenta development reproductive process chordate embryonic development developmental process involved in reproduction embryo development in utero embryonic development trophoblast giant cell differentiation embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development cell cycle comprising mitosis without cytokinesis mitotic cell cycle fibroblast proliferation cell population proliferation positive regulation of DNA replication positive regulation of DNA endoreduplication positive regulation of biological process cell cycle DNA replication regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of cell cycle process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process DNA-templated DNA replication positive regulation of nucleobase-containing compound metabolic process DNA endoreduplication primary metabolic process DNA metabolic process regulation of macromolecule metabolic process positive regulation of cell cycle nucleic acid metabolic process organic cyclic compound metabolic process DNA replication positive regulation of DNA metabolic process regulation of DNA endoreduplication positive regulation of DNA-templated DNA replication regulation of DNA-templated DNA replication metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication epithelium development gland development tissue development liver development epithelial cell differentiation hepaticobiliary system development hepatocyte differentiation cellular biosynthetic process RNA metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RNA polymerase II transcription regulator complex protein-containing complex nuclear protein-containing complex transcription regulator complex cytoplasm cytosol nucleoplasm protein-DNA complex chromatin chromosome
B [auth C]	DNA (5'-D(PTPTPTPTPCPCPCPGPCPCPAPAPAPAP*A)-3')	-	-	-
C [auth D]	DNA (5'-D(PTPTPTPTPTPGPGPCPGPGPGPAPAPAP*A)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003316	E2F/DP family, winged-helix DNA-binding domain	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR015633	E2F Family	Family
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: A0AVK6	non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis atopic eczema cystic fibrosis glioblastoma invasive ductal breast carcinoma lung adenocarcinoma malignant glioma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm retinal disease atypical teratoid rhabdoid tumor ductal breast carcinoma in situ non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis atopic eczema cystic fibrosis glioblastoma invasive ductal breast carcinoma lung adenocarcinoma malignant glioma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm retinal disease atypical teratoid rhabdoid tumor ductal breast carcinoma in situ hepatocellular carcinoma juvenile dermatomyositis lung cancer malignant mesothelioma Neoplasm Metastasis ovarian cancer primitive neuroectodermal tumor breast cancer endometriosis interstitial cystitis large cell medulloblastoma malignant ependymoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.