Annotations: 4YLI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00059	e4yliA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
F	PF00059	e4yliF1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
B	PF00059	e4yliB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
C	PF00059	e4yliC1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
D	PF00059	e4yliD1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
E	PF00059	e4yliE1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
F	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
E	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01391	Collagen triple helix repeat (20 copies) (Collagen)	Collagen triple helix repeat (20 copies)	-	Repeat
A, B, C, D, E A, B, C, D, E, F	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Collectin-11	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding oligosaccharide binding carbohydrate binding mannose binding monosaccharide binding DNA binding organic cyclic compound binding nucleic acid binding fucose binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding oligosaccharide binding carbohydrate binding mannose binding monosaccharide binding DNA binding organic cyclic compound binding nucleic acid binding fucose binding calcium-dependent carbohydrate binding identical protein binding protein binding	cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway cellular response to stimulus positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus pattern recognition receptor signaling pathway response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus signaling positive regulation of biological process innate immune response activating cell surface receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus cell surface pattern recognition receptor signaling pathway positive regulation of innate immune response cell surface receptor signaling pathway defense response biological regulation defense response to symbiont immune system process cellular process humoral immune response complement activation complement activation, lectin pathway immune effector process execution phase of apoptosis apoptotic process cell death programmed cell death developmental process antimicrobial humoral response regulation of immune effector process import into cell regulation of localization positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization opsonization localization positive regulation of endocytosis positive regulation of immune effector process phagocytosis cell recognition cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of opsonization regulation of opsonization phagocytosis, recognition positive regulation of phagocytosis positive regulation of transport endocytosis organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	protein-containing complex collagen trimer cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular region catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex protein-containing complex collagen trimer cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular region catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex serine-type peptidase complex extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008160	Collagen triple helix repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001304	C-type lectin-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018378	C-type lectin, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR033990	Collectin, C-type lectin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9BWP8	3MC syndrome 3MC syndrome 2 3MC syndrome 3 Craniofacial Abnormalities pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous carcinoma 3MC syndrome 1 adenoma chronic kidney disease craniosynostosis Ito hypomelanosis nephrosclerosis 3MC syndrome 3MC syndrome 2 3MC syndrome 3 Craniofacial Abnormalities pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous carcinoma 3MC syndrome 1 adenoma chronic kidney disease craniosynostosis Ito hypomelanosis nephrosclerosis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm adrenal cortex carcinoma dental caries malignant pancreatic neoplasm nevus of Ito

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.