Annotations: 4YL8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4yl8a2	All alpha proteins	Acyl-CoA binding protein-like	Second domain of FERM	Second domain of FERM	Moesin	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d4yl8a3	All beta proteins	PH domain-like barrel	PH domain-like	Third domain of FERM	Moesin	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d4yl8a1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Ubiquitin-like	First domain of FERM	Moesin	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FERM_C	e4yl8A3	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: FERM_C	ECOD (1.6)
A	FERM_M	e4yl8A2	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: FERM_M	ECOD (1.6)
A	FERM_N	e4yl8A1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: FERM_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
A	1.20.80.10	Mainly Alpha	Up-down Bundle	Acyl-CoA Binding Protein		CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09379	FERM N-terminal domain (FERM_N)	FERM N-terminal domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	Domain
A	PF09380	FERM C-terminal PH-like domain (FERM_C)	FERM C-terminal PH-like domain	-	Domain
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Moesin	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding protein binding signaling receptor binding cell adhesion molecule binding kinase binding enzyme binding protein kinase binding cytoskeletal protein binding actin binding	membrane to membrane docking cellular process membrane docking regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process membrane to membrane docking cellular process membrane docking regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size leukocyte migration immune system process mononuclear cell migration lymphocyte migration cell migration T cell migration cell motility regulation of cellular component organization organelle assembly regulation of cellular component biogenesis regulation of organelle organization cellular component biogenesis organelle organization cellular component assembly regulation of organelle assembly multicellular organismal process cell population proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation developmental process anatomical structure morphogenesis gland morphogenesis gland development animal organ development anatomical structure development animal organ morphogenesis T cell aggregation cell adhesion cell-cell adhesion lymphocyte aggregation leukocyte cell-cell adhesion leukocyte aggregation positive regulation of organelle organization positive regulation of cellular component organization non-membrane-bounded organelle assembly positive regulation of podosome assembly positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly regulation of podosome assembly protein-containing complex assembly podosome assembly positive regulation of cellular component biogenesis protein-containing complex organization positive regulation of organelle assembly catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process organic substance catabolic process regulation of protein catabolic process polarized epithelial cell differentiation establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity cellular developmental process establishment or maintenance of cell polarity epithelial cell differentiation morphogenesis of a polarized epithelium cell differentiation establishment or maintenance of apical/basal cell polarity establishment or maintenance of bipolar cell polarity epithelium development establishment of epithelial cell apical/basal polarity morphogenesis of an epithelium tissue development establishment of cell polarity tissue morphogenesis establishment or maintenance of epithelial cell apical/basal polarity establishment of apical/basal cell polarity establishment of epithelial cell polarity protein localization regulation of localization cellular localization positive regulation of protein localization to early endosome regulation of protein localization protein localization to endosome protein localization to early endosome localization regulation of protein localization to endosome regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of protein localization to endosome regulation of protein localization to early endosome regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis endothelial cell differentiation endothelium development cell development endothelial cell development epithelial cell development establishment of endothelial barrier cellular response to testosterone stimulus cellular response to stimulus response to organic substance response to ketone response to stimulus response to lipid cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound response to testosterone cellular response to chemical stimulus response to chemical cellular response to lipid cellular response to organic substance cellular response to ketone response to organic cyclic compound immunological synapse formation cell-cell recognition cell recognition positive regulation of early endosome to late endosome transport transport vesicle-mediated transport establishment of localization in cell positive regulation of intracellular transport regulation of intracellular transport regulation of transport intracellular transport regulation of vesicle-mediated transport establishment of localization endosomal transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport positive regulation of transport regulation of cell motility regulation of leukocyte migration regulation of lymphocyte migration regulation of locomotion regulation of cell migration regulation of immune system process regulation of mononuclear cell migration locomotion	cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection cell periphery sarcolemma plasma membrane membrane T-tubule apical part of cell intracellular anatomical structure cytoplasm cytosol actin-based cell projection cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection cell periphery sarcolemma plasma membrane membrane T-tubule apical part of cell intracellular anatomical structure cytoplasm cytosol actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane basal part of cell basal plasma membrane basolateral plasma membrane cell-cell junction adherens junction anchoring junction cell junction intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle perinuclear region of cytoplasm filopodium cell tip cell pole focal adhesion cell-substrate junction myelin sheath apical plasma membrane cell surface uropod cell trailing edge cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane filopodium membrane
B	Protein crumbs	protein binding binding signaling receptor binding Notch binding cytoskeletal protein binding spectrin binding protein-containing complex binding cation binding ion binding calcium ion binding metal ion binding small molecule binding kinase binding protein kinase C binding protein binding binding signaling receptor binding Notch binding cytoskeletal protein binding spectrin binding protein-containing complex binding cation binding ion binding calcium ion binding metal ion binding small molecule binding kinase binding protein kinase C binding enzyme binding protein kinase binding	adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development regulation of protein stability biological regulation regulation of biological quality protein stabilization adherens junction assembly apical junction assembly cellular component biogenesis cellular component assembly cell junction assembly zonula adherens assembly cell-cell junction assembly localization centrosome localization microtubule organizing center localization respiratory system development open tracheal system development cell division tube morphogenesis tube development nuclear chromosome segregation cell cycle chromosome segregation cell cycle process cellular developmental process rhabdomere development sensory organ development photoreceptor cell differentiation cell projection organization plasma membrane bounded cell projection morphogenesis visual system development cell development neuron projection development cell morphogenesis eye morphogenesis neurogenesis photoreceptor cell morphogenesis cell projection morphogenesis compound eye morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation eye photoreceptor cell differentiation sensory system development photoreceptor cell development plasma membrane bounded cell projection organization eye development eye photoreceptor cell development nervous system development compound eye photoreceptor development cell morphogenesis involved in neuron differentiation generation of neurons compound eye development organelle organization sensory organ morphogenesis compound eye photoreceptor cell differentiation rhabdomere morphogenesis neuron development regulation of biological process regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth negative regulation of biological process organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process trachea development regulation of imaginal disc growth imaginal disc growth imaginal disc development protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of protein transport establishment of localization protein transport regulation of cellular localization macromolecule localization regulation of intracellular protein transport intracellular protein transport catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process negative regulation of protein catabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process metabolic process macromolecule metabolic process organic substance catabolic process regulation of metabolic process regulation of protein catabolic process establishment or maintenance of cell polarity Malpighian tubule development embryo development renal system development renal tubule development hindgut development epithelial tube morphogenesis epithelium development Malpighian tubule morphogenesis digestive system development embryonic morphogenesis hindgut morphogenesis morphogenesis of an epithelium tissue development digestive tract development tissue morphogenesis digestive tract morphogenesis embryonic hindgut morphogenesis renal tubule morphogenesis dorsal/ventral pattern formation, imaginal disc wing disc development pattern specification process wing disc dorsal/ventral pattern formation regionalization imaginal disc pattern formation dorsal/ventral pattern formation wing disc pattern formation apical protein localization morphogenesis of embryonic epithelium dorsal closure embryonic development via the syncytial blastoderm dorsal closure, amnioserosa morphology change embryo development ending in birth or egg hatching homeostatic process tissue homeostasis amnioserosa maintenance multicellular organismal-level homeostasis anatomical structure homeostasis actin cytoskeleton organization actomyosin structure organization cortical cytoskeleton organization assembly of apicomedial cortex actomyosin cortical actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular component maintenance adherens junction maintenance cell junction maintenance zonula adherens maintenance cell-cell junction maintenance actin filament-based movement epithelial cell differentiation epithelial cell development epithelial cell morphogenesis actin-mediated cell contraction apical constriction establishment or maintenance of bipolar cell polarity establishment or maintenance of apical/basal cell polarity maintenance of cell polarity maintenance of apical/basal cell polarity morphogenesis of follicular epithelium establishment or maintenance of polarity of follicular epithelium establishment or maintenance of polarity of embryonic epithelium cellular response to stimulus hippo signaling positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus positive regulation of hippo signaling regulation of cell communication regulation of hippo signaling positive regulation of signaling negative regulation of signaling negative regulation of cell communication negative regulation of cellular process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway epithelial fluid transport liquid clearance, open tracheal system fluid transport transepithelial transport retina homeostasis photoreceptor cell maintenance membrane organization cell morphogenesis involved in Malpighian tubule morphogenesis	membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection cellular anatomical entity plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium rhabdomere intracellular anatomical structure membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection cellular anatomical entity plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium rhabdomere intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane rhabdomere membrane cell projection membrane cell-cell junction protein-containing complex plasma membrane protein complex anchoring junction membrane protein complex apical junction complex cell junction subapical complex apicolateral plasma membrane nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000299	FERM domain	Domain
A	IPR019748	FERM central domain	Domain
A	IPR018980	FERM, C-terminal PH-like domain	Domain
A	IPR000798	Ezrin/radixin/moesin-like	Family
A	IPR008954	Moesin tail domain superfamily	Homologous Superfamily
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR011259	Ezrin/radixin/moesin, C-terminal	Domain
A	IPR019747	FERM conserved site	Conserved Site
A	IPR018979	FERM, N-terminal	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR041789	ERM family, FERM domain C-lobe	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR046810	Ezrin/radixin/moesin, alpha-helical domain	Domain
A	IPR019749	Band 4.1 domain	Domain
A	IPR011174	Ezrin/radixin/moesin	Family
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B	IPR013032	EGF-like, conserved site	Conserved Site
B	IPR001881	EGF-like calcium-binding domain	Domain
B	IPR000742	EGF-like domain	Domain
B	IPR001791	Laminin G domain	Domain
B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM