Annotations: 4YJ0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00751	e4yj0A1	A: few secondary structure elements	X: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	H: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	T: Cysteine-rich DNA binding domain, (DM domain)	F: PF00751	ECOD (1.6)
B	PF00751	e4yj0B1	A: few secondary structure elements	X: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	H: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	T: Cysteine-rich DNA binding domain, (DM domain)	F: PF00751	ECOD (1.6)
C	PF00751	e4yj0C1	A: few secondary structure elements	X: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	H: Cysteine-rich DNA binding domain, (DM domain) (From Topology)	T: Cysteine-rich DNA binding domain, (DM domain)	F: PF00751	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF12374	Double-sex mab3 related transcription factor 1 (Dmrt1)	Double-sex mab3 related transcription factor 1	-	Family
A, B, C	PF00751	DM DNA binding domain (DM)	DM DNA binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Doublesex- and mab-3-related transcription factor 1	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	multicellular organismal process cellular developmental process reproductive process sex differentiation developmental process involved in reproduction epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics cell differentiation anatomical structure development multicellular organismal process cellular developmental process reproductive process sex differentiation developmental process involved in reproduction epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics cell differentiation anatomical structure development reproductive structure development system development developmental process epithelium development gonad development reproductive system development animal organ development tissue development cellular process spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation germ cell migration cell migration cell motility sex determination male sex determination meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization meiosis I meiosis I cell cycle process meiotic nuclear division cell cycle cellular component organization or biogenesis cell cycle process oogenesis cell development cellular process involved in reproduction in multicellular organism female gamete generation oocyte development germ cell development oocyte differentiation regulation of developmental process regulation of gonad development regulation of reproductive process positive regulation of biological process positive regulation of developmental process positive regulation of male gonad development regulation of multicellular organismal process regulation of male gonad development positive regulation of reproductive process regulation of biological process biological regulation positive regulation of gonad development positive regulation of multicellular organismal process positive regulation of organelle organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process regulation of cell cycle positive regulation of cellular process mitotic nuclear division regulation of cell cycle process positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle mitotic cell cycle process regulation of nuclear division germ cell proliferation cell population proliferation male germ cell proliferation cellular response to stimulus regulation of signaling activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction cell communication nodal signaling pathway regulation of nodal signaling pathway regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway signal transduction regulation of activin receptor signaling pathway enzyme-linked receptor protein signaling pathway anatomical structure morphogenesis cell morphogenesis cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of meiosis I regulation of meiotic cell cycle positive regulation of meiotic cell cycle regulation of meiotic nuclear division positive regulation of meiosis I positive regulation of meiotic nuclear division Sertoli cell development epithelial cell development intracellular signal transduction negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process negative regulation of cell cycle negative regulation of meiotic nuclear division negative regulation of cellular component organization negative regulation of cell cycle process negative regulation of nuclear division negative regulation of organelle organization negative regulation of reproductive process negative regulation of meiotic cell cycle positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus germ cell nucleus intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus germ cell nucleus intracellular membrane-bounded organelle female germ cell nucleus
D	DNA (25-MER)	-	-	-
E	DNA (25-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR022114	Doublesex- and mab-3-related transcription factor 1-like	Family
A, B, C	IPR001275	DM DNA-binding domain	Domain
A, B, C	IPR026607	DMRT family	Family
A, B, C	IPR036407	DM DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9Y5R6	46,XY complete gonadal dysgenesis testicular cancer testicular germ cell tumor gonadal dysgenesis embryonal neoplasm germ cell tumor Cancer, Embryonal and Mixed 46,XY sex reversal 4 uterine corpus leiomyoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.