Annotations: 4YEQ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth U]	PF00754	e4yeqU1	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF00754	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth U]	PF00052	Laminin B (Domain IV) (Laminin_B)	Laminin B (Domain IV)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth U]	Laminin subunit alpha-2	protein binding binding signaling receptor binding structural molecule activity	developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation cell differentiation developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation muscle cell differentiation positive regulation of muscle cell differentiation muscle structure development positive regulation of developmental process regulation of muscle cell differentiation positive regulation of cell differentiation cell differentiation anatomical structure development cellular process positive regulation of cellular process animal organ development muscle organ development multicellular organismal process peripheral nervous system development nervous system development multicellular organism development neurogenesis gliogenesis glial cell differentiation Schwann cell differentiation system development regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion cell adhesion positive regulation of cell adhesion regulation of cell adhesion cellular response to stimulus positive regulation of cell communication regulation of integrin-mediated signaling pathway positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell communication positive regulation of response to stimulus positive regulation of integrin-mediated signaling pathway signal transduction regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis regulation of embryonic development regulation of multicellular organismal development embryo development regulation of multicellular organismal process regulation of cellular component organization extracellular matrix organization regulation of basement membrane organization regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization basement membrane organization modulation of chemical synaptic transmission synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission, cholinergic cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling synaptic transmission, cholinergic regulation of synaptic transmission, cholinergic	basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity sarcolemma plasma membrane membrane synaptic cleft extracellular region neuromuscular junction synapse cell junction basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity sarcolemma plasma membrane membrane synaptic cleft extracellular region neuromuscular junction synapse cell junction neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree protein-containing complex protein complex involved in cell-matrix adhesion protein complex involved in cell adhesion

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth U]	IPR008211	Laminin, N-terminal	Domain
A [auth U]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A [auth U]	IPR002049	Laminin-type EGF domain	Domain
A [auth U]	IPR010307	Laminin domain II	Domain
A [auth U]	IPR000742	EGF-like domain	Domain
A [auth U]	IPR001791	Laminin G domain	Domain
A [auth U]	IPR009254	Laminin alpha, domain I	Domain
A [auth U]	IPR000034	Laminin IV	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth U]	Pharos: P24043	congenital merosin-deficient muscular dystrophy 1A muscular dystrophy myopathy congenital muscular dystrophy limb-girdle muscular dystrophy schizophrenia urinary bladder cancer myopia malignant colon neoplasm malignant pancreatic neoplasm muscle tissue disease Muscular Dystrophy, Congenital, due to Partial LAMA2 Deficiency ovarian cancer adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm congenital merosin-deficient muscular dystrophy 1A muscular dystrophy myopathy congenital muscular dystrophy limb-girdle muscular dystrophy schizophrenia urinary bladder cancer myopia malignant colon neoplasm malignant pancreatic neoplasm muscle tissue disease Muscular Dystrophy, Congenital, due to Partial LAMA2 Deficiency ovarian cancer adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm attention deficit hyperactivity disorder, inattentive type breast carcinoma ductal breast carcinoma in situ intellectual disability lung cancer malignant ependymoma medulloblastoma muscular disease pancreatic ductal adenocarcinoma arthrogryposis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor Charcot-Marie-Tooth disease Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma lung carcinoma motor peripheral neuropathy pancreatic intraductal papillary-mucinous carcinoma atopic eczema psoriasis breast cancer urinary bladder neoplasm cholangiocarcinoma Duchenne muscular dystrophy glioblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.