Annotations: 4YE6

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Gln-tRNA synthetase (GlnRS) C-terminal (anticodon-binding) domain	8092912	4002383	SCOP2 (2022-06-29)
A	SCOP2 Family	GlnRS nsRDB1-like	8092917	4004891	SCOP2 (2022-06-29)
A	SCOP2 Family	GlnRS nsRDB2-like	8046133	4004894	SCOP2 (2022-06-29)
A	SCOP2 Family	Class I aminoacyl-tRNA synthetases (RS) catalytic domain	8046128	4003807	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribosomal protein L25-like	8092913	3001161	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GlnRS nsRDB1-like	8092921	3002643	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GlnRS nsRDB2-like	8092920	3002645	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleotidylyl transferase	8092911	3001541	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03950	e4ye6A3	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: PF03950	ECOD (1.6)
A	PF20974	e4ye6A2	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: PF20974	ECOD (1.6)
A	PF04558	e4ye6A4	A: alpha arrays	X: ERP29 C domain-like	H: GatB/GatE C-terminal domain (From Topology)	T: GatB/GatE C-terminal domain	F: PF04558	ECOD (1.6)
A	PF00749	e4ye6A7	A: alpha bundles	X: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	H: Zn-binding domain in glutaminyl-tRNA synthetase (From Topology)	T: Zn-binding domain in glutaminyl-tRNA synthetase	F: PF00749	ECOD (1.6)
A	PF00749,PF04557	e4ye6A5	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00749,PF04557	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00749	tRNA synthetases class I (E and Q), catalytic domain (tRNA-synt_1c)	tRNA synthetases class I (E and Q), catalytic domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain
A	PF03950	tRNA synthetases class I (E and Q), anti-codon binding domain (tRNA-synt_1c_C)	tRNA synthetases class I (E and Q), anti-codon binding domain	This entry represents the first of the two ribosomal L25-like domains of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some o ...	This entry represents the first of the two ribosomal L25-like domains of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain
A	PF04558	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 (tRNA_synt_1c_R1)	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1	-	Family
A	PF04557	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 (tRNA_synt_1c_R2)	Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2	-	Family
A	PF20974	tRNA synthetases class I (E and Q), anti-codon binding domain (tRNA-synt_1c_C2)	tRNA synthetases class I (E and Q), anti-codon binding domain	This entry represents the second ribosomal L25 like domain which is part of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In som ...	This entry represents the second ribosomal L25 like domain which is part of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glutamine--tRNA ligase	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ligase activity, forming carbon-oxygen bonds aminoacyl-tRNA ligase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid glutamine-tRNA ligase activity catalytic activity, acting on a tRNA catalytic activity ligase activity protein binding kinase binding enzyme binding protein kinase binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of stress-activated MAPK cascade regulation of cellular response to stress regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication stress-activated MAPK cascade cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade negative regulation of signal transduction regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade regulation of response to stimulus negative regulation of stress-activated protein kinase signaling cascade MAPK cascade regulation of cell communication negative regulation of MAPK cascade developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development amino acid activation tRNA aminoacylation organonitrogen compound biosynthetic process amino acid metabolic process protein metabolic process organonitrogen compound metabolic process translation tRNA aminoacylation for protein translation tRNA metabolic process ncRNA metabolic process regulation of programmed cell death negative regulation of apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process cell death apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation glutaminyl-tRNA aminoacylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex membrane-bounded organelle mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042559	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2	Homologous Superfamily
A	IPR007638	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2	Domain
A	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site	Conserved Site
A	IPR042558	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1	Homologous Superfamily
A	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A	IPR004514	Glutamine-tRNA synthetase	Family
A	IPR007639	Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal	Domain
A	IPR000924	Glutamyl/glutaminyl-tRNA synthetase	Family
A	IPR020058	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain	Domain
A	IPR020056	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal	Homologous Superfamily
A	IPR049437	tRNA synthetases class I (E and Q), anti-codon binding domain	Domain
A	IPR020059	Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain	Domain
A	IPR011035	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P47897	diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome prostate cancer microcephaly Primary microcephaly astrocytic tumor endogenous depression intellectual disability medulloblastoma myocardial infarction ovarian cancer atypical teratoid rhabdoid tumor endometriosis glioblastoma large cell medulloblastoma oligodendroglioma diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome prostate cancer microcephaly Primary microcephaly astrocytic tumor endogenous depression intellectual disability medulloblastoma myocardial infarction ovarian cancer atypical teratoid rhabdoid tumor endometriosis glioblastoma large cell medulloblastoma oligodendroglioma plasma cell myeloma epilepsy heart disease lymphoplasmacytic lymphoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.