Annotations: 4XWW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00753,PF07521	e4xwwA1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF00753,PF07521	ECOD (1.6)
A	PF17770	e4xwwA3	A: a+b complex topology	X: Flagellar protein FlgA N-terminal domain-like	H: RNase J C-terminal domain (From Topology)	T: RNase J C-terminal domain	F: PF17770	ECOD (1.6)
A	PF22505	e4xwwA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF22505	ECOD (1.6)
B	PF00753,PF07521	e4xwwB2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF00753,PF07521	ECOD (1.6)
B	PF17770	e4xwwB3	A: a+b complex topology	X: Flagellar protein FlgA N-terminal domain-like	H: RNase J C-terminal domain (From Topology)	T: RNase J C-terminal domain	F: PF17770	ECOD (1.6)
B	PF22505	e4xwwB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF22505	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
A	3.40.50.10710	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Metallo-hydrolase/oxidoreductase	CATH (4.3.0)
A	3.10.20.580	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
B	3.60.15.10	Alpha Beta	4-Layer Sandwich	Metallo-beta-lactamase	Chain A	CATH (4.3.0)
B	3.40.50.10710	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Metallo-hydrolase/oxidoreductase	CATH (4.3.0)
B	3.10.20.580	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07521	Zn-dependent metallo-hydrolase RNA specificity domain (RMMBL)	Zn-dependent metallo-hydrolase RNA specificity domain	-	Motif
A, B	PF17770	Ribonuclease J C-terminal domain (RNase_J_C)	Ribonuclease J C-terminal domain	This domain is found at the C-terminus of Ribonuclease J proteins. Its function is unknown, but deletion of this domain causes dissociation to monomers [2].	Domain
A, B	PF00753	Metallo-beta-lactamase superfamily (Lactamase_B)	Metallo-beta-lactamase superfamily	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DR2417	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity 5'-3' RNA exonuclease activity 5'-3' exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters RNA exonuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity 5'-3' RNA exonuclease activity 5'-3' exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters RNA exonuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters exonuclease activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity
C [auth D], D [auth E]	RNA (5'-D(UPUPUPUPUPUPU)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001279	Metallo-beta-lactamase	Domain
A, B	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
A, B	IPR004613	Ribonuclease J	Family
A, B	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A, B	IPR030854	Ribonuclease J, bacteria	Family
A, B	IPR041636	Ribonuclease J, C-terminal	Domain
A, B	IPR042173	Ribonuclease J, domain 2	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.