4XST

Structure of the endoglycosidase-H treated L1-CR domains of the human insulin receptor in complex with residues 697-719 of the human insulin receptor (A-isoform)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth E]	SCOP2B Superfamily	Growth factor receptor domain-like	8032837	3000398	SCOP2B (2022-06-29)
A [auth E]	SCOP2B Superfamily	L domain-like	8032830	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	PF01030	e4xstE1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF01030	ECOD (1.6)
A [auth E]	PF00757	e4xstE2	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: PF00757	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth E]	3.80.20.20	Alpha Beta	Alpha-Beta Horseshoe	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'	Chain A	CATH (4.3.0)
A [auth E]	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E]	PF01030	Receptor L domain (Recep_L_domain)	Receptor L domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	Insulin receptor	protein binding binding insulin receptor substrate binding amide binding amyloid-beta binding peptide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity protein binding binding insulin receptor substrate binding amide binding amyloid-beta binding peptide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein-hormone receptor activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity insulin receptor activity catalytic activity PTB domain binding protein domain specific binding phosphatidylinositol 3-kinase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding identical protein binding insulin-like growth factor receptor binding signaling receptor binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding cargo receptor activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding insulin-like growth factor I binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular component disassembly positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular process cellular component organization or biogenesis positive regulation of protein-containing complex disassembly positive regulation of cellular process behavior system process learning learning or memory nervous system process cognition localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of phosphorylation regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth positive regulation of developmental process positive regulation of growth positive regulation of developmental growth memory positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division protein autophosphorylation heart development heart morphogenesis circulatory system development anatomical structure morphogenesis animal organ morphogenesis digestive system development gland development exocrine pancreas development pancreas development exocrine system development positive regulation of respiratory burst respiratory burst regulation of respiratory burst cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of meiotic cell cycle sexual reproduction regulation of reproductive process meiotic cell cycle positive regulation of meiotic cell cycle positive regulation of reproductive process circulatory system process vascular process in circulatory system vascular transport transport across blood-brain barrier biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process cellular catabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process sex determination male sex determination positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen metabolic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of cellular biosynthetic process glucose metabolic process regulation of localization regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport amyloid-beta clearance epidermis development tissue development cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling regulation of gonad development development of primary female sexual characteristics regulation of female gonad development regulation of multicellular organismal process regulation of multicellular organismal development female gonad development female sex differentiation cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade regulation of MAPK cascade regulation of protein serine/threonine kinase activity MAPK cascade dendritic spine maintenance dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization cellular component maintenance cell junction organization neuron projection organization synapse organization adrenal gland development endocrine system development cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus cellular response to growth factor stimulus response to growth factor positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process regulation of embryonic development embryo development G protein-coupled receptor signaling pathway neuron projection maintenance hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport organic substance transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex receptor complex endosome membrane intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle cytoplasm organelle membrane somatodendritic compartment neuronal cell body membrane cell body cell body membrane neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola lytic vacuole vacuole lysosome cell leading edge leading edge membrane neuron projection membrane dendrite membrane dendrite dendritic tree cell projection membrane catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups insulin receptor complex plasma membrane signaling receptor complex late endosome
B [auth F]	Insulin receptor	amide binding amyloid-beta binding binding peptide binding protein binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity amide binding amyloid-beta binding binding peptide binding protein binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein-hormone receptor activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity insulin receptor activity catalytic activity protein phosphatase binding phosphatase binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding 3-phosphoinositide-dependent protein kinase binding kinase binding protein kinase binding protein-containing complex binding insulin-like growth factor receptor binding signaling receptor binding protein domain specific binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding structural molecule activity insulin receptor substrate binding PTB domain binding phosphatidylinositol 3-kinase binding fatty acid binding organic acid binding lipid binding lipoic acid binding carboxylic acid binding monocarboxylic acid binding sulfur compound binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding cargo receptor activity insulin-like growth factor I binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular component disassembly positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly cellular component organization cellular process cellular component organization or biogenesis positive regulation of protein-containing complex disassembly positive regulation of cellular process response to organic substance response to ketone response to lipid response to stimulus response to chemical response to oxygen-containing compound response to testosterone response to organic cyclic compound developmental process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth positive regulation of developmental process positive regulation of growth positive regulation of developmental growth regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development positive regulation of organelle organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle regulation of mitotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division regulation of generation of precursor metabolites and energy organic substance biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process carbohydrate biosynthetic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of glycogen metabolic process regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds cellular biosynthetic process regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process cellular response to stimulus response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels cellular response to stress response to stress response to starvation cellular response to zinc ion starvation RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process gene expression nucleic acid metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of DNA-templated transcription fat cell differentiation cellular developmental process cell differentiation biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction response to vanadate(3-) response to inorganic substance pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process cellular catabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process positive regulation of cellular metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of phosphate metabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process response to metal ion response to manganese ion positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process positive regulation of macromolecule metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process monosaccharide metabolic process regulation of glucose metabolic process positive regulation of cellular biosynthetic process glucose metabolic process response to activity epidermis development tissue development gland development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration response to hexose response to monosaccharide response to carbohydrate response to glucose reactive oxygen species metabolic process hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process regulation of reactive oxygen species metabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation dendritic spine maintenance dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization cellular component maintenance cell junction organization neuron projection organization synapse organization adrenal gland development endocrine system development cellular response to nitrogen compound signaling response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to insulin cellular response to insulin stimulus cellular response to growth factor stimulus response to growth factor positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion embryonic organ development embryo development embryonic liver development positive regulation of phosphorylation regulation of embryonic development regulation of multicellular organismal development regulation of multicellular organismal process G protein-coupled receptor signaling pathway negative regulation of gene expression neuron projection maintenance regulation of localization hexose transmembrane transport glucose import transport carbohydrate transport localization positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport regulation of transport organic substance transport establishment of localization transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport positive regulation of transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport response to estradiol gonad development reproductive system development reproductive process sex differentiation developmental process involved in reproduction male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development import into cell receptor internalization receptor-mediated endocytosis endocytosis vesicle-mediated transport heart development heart morphogenesis circulatory system development anatomical structure morphogenesis animal organ morphogenesis digestive system development exocrine pancreas development pancreas development exocrine system development positive regulation of respiratory burst respiratory burst regulation of respiratory burst regulation of meiotic cell cycle sexual reproduction regulation of reproductive process meiotic cell cycle positive regulation of meiotic cell cycle positive regulation of reproductive process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis response to stilbenoid response to resveratrol gluconeogenesis small molecule biosynthetic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis forebrain development pallium development telencephalon development hippocampus development limbic system development sex determination male sex determination regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization amyloid-beta clearance positive regulation of glycoprotein metabolic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling response to corticosteroid response to steroid hormone response to glucocorticoid regulation of gonad development development of primary female sexual characteristics regulation of female gonad development female gonad development female sex differentiation response to alcohol response to ethanol positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade response to vitamin D response to nutrient response to vitamin positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of protein modification process positive regulation of protein phosphorylation negative regulation of feeding behavior negative regulation of behavior feeding behavior regulation of behavior behavior regulation of feeding behavior negative regulation of multicellular organismal process response to food response to cytokine response to tumor necrosis factor	protein-containing complex receptor complex intracellular anatomical structure cytoplasm cellular anatomical entity yolk membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola protein-containing complex receptor complex intracellular anatomical structure cytoplasm cellular anatomical entity yolk membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome cell leading edge neuron projection leading edge membrane plasma membrane bounded cell projection somatodendritic compartment neuron projection membrane cell projection dendrite membrane dendrite dendritic tree cell projection membrane endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle late endosome cell surface external side of plasma membrane side of membrane cell body neuronal cell body neuronal cell body membrane cell body membrane axon catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups insulin receptor complex plasma membrane signaling receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E]	IPR008266	Tyrosine-protein kinase, active site	Active Site
A [auth E]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A [auth E]	IPR000719	Protein kinase domain	Domain
A [auth E]	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
A [auth E]	IPR006212	Furin-like repeat	Repeat
A [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth E]	IPR000494	Receptor L-domain	Domain
A [auth E]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth E]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A [auth E]	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A [auth E]	IPR003961	Fibronectin type III	Domain
A [auth E]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth E]	IPR006211	Furin-like cysteine-rich domain	Domain
A [auth E]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A [auth E]	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
A [auth E]	IPR040969	Insulin receptor, trans-membrane domain	Domain
A [auth E]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B [auth F]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
B [auth F]	IPR000719	Protein kinase domain	Domain
B [auth F]	IPR006212	Furin-like repeat	Repeat
B [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth F]	IPR017441	Protein kinase, ATP binding site	Binding Site
B [auth F]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
B [auth F]	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
B [auth F]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B [auth F]	IPR008266	Tyrosine-protein kinase, active site	Active Site
B [auth F]	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
B [auth F]	IPR000494	Receptor L-domain	Domain
B [auth F]	IPR003961	Fibronectin type III	Domain
B [auth F]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth F]	IPR006211	Furin-like cysteine-rich domain	Domain
B [auth F]	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
B [auth F]	IPR040969	Insulin receptor, trans-membrane domain	Domain
B [auth F]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E]	Pharos: P06213	Donohue syndrome type 2 diabetes mellitus hyperinsulinism due to INSR deficiency Rabson-Mendenhall syndrome Insulin Resistance Alzheimer disease glucose intolerance hyperinsulinism insulin-resistance syndrome type A polycystic ovary syndrome Parkinson disease diabetic autonomic neuropathy diabetic neuropathy congenital diaphragmatic hernia hyperglycemia Donohue syndrome type 2 diabetes mellitus hyperinsulinism due to INSR deficiency Rabson-Mendenhall syndrome Insulin Resistance Alzheimer disease glucose intolerance hyperinsulinism insulin-resistance syndrome type A polycystic ovary syndrome Parkinson disease diabetic autonomic neuropathy diabetic neuropathy congenital diaphragmatic hernia hyperglycemia diabetic polyneuropathy Lewy body dementia diabetes mellitus psoriasis spina bifida substance-related disorder intellectual disability acquired metabolic disease drug dependence lung disease malignant glioma maturity-onset diabetes of the young glioblastoma osteogenesis imperfecta pancreatic ductal adenocarcinoma hyperinsulinemic hypoglycemia hypertensive disorder substance dependence large cell medulloblastoma type 1 diabetes mellitus esophageal adenocarcinoma malignant mesothelioma atypical teratoid rhabdoid tumor osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma dermatomyositis Sjogren syndrome hypothyroidism substance abuse malignant ependymoma exocrine pancreatic carcinoma malignant pancreatic neoplasm astrocytic tumor gastric adenocarcinoma breast cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia