4XNW

The human P2Y1 receptor in complex with MRS2500

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091220	3000473	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091220	3000473	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Rubredoxin-like	8039183	3001257	SCOP2B (2022-06-29)
B [auth C]	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091219	4001858	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Superfamily	G protein-coupled receptor-like	8091220	3000473	SCOP2 (2022-06-29)
B [auth C]	SCOP2B Superfamily	Rubredoxin-like	8039183	3001257	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00001	e4xnwA1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: PF00001	ECOD (1.6)
A	PF00301	e4xnwA2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF00301	ECOD (1.6)
B [auth C]	PF00001	e4xnwC1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: PF00001	ECOD (1.6)
B [auth C]	PF00301	e4xnwC2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF00301	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family
A, B [auth C]	PF00301	Rubredoxin (Rubredoxin)	Rubredoxin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1	electron transfer activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding A1 adenosine receptor binding protein binding signaling receptor binding G protein-coupled receptor binding adenosine receptor binding adenyl ribonucleotide binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding A1 adenosine receptor binding protein binding signaling receptor binding G protein-coupled receptor binding adenosine receptor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding ADP binding G protein-coupled purinergic nucleotide receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity purinergic nucleotide receptor activity nucleotide receptor activity G protein-coupled ATP receptor activity protein heterodimerization activity protein dimerization activity scaffold protein binding G protein-coupled ADP receptor activity	multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process reproductive process multicellular organismal reproductive process biological regulation positive regulation of biological process mating behavior behavior positive regulation of penile erection positive regulation of multicellular organismal process reproductive behavior regulation of multicellular organismal process multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process reproductive process multicellular organismal reproductive process biological regulation positive regulation of biological process mating behavior behavior positive regulation of penile erection positive regulation of multicellular organismal process reproductive behavior regulation of multicellular organismal process penile erection copulation positive regulation of reproductive process positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of biological quality positive regulation of cellular process regulation of signaling regulation of transport secretion regulation of hormone levels export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling monoatomic ion transport protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane cellular response to stimulus purinergic nucleotide receptor signaling pathway response to stimulus cell surface receptor signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction G protein-coupled adenosine receptor signaling pathway regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation response to wounding platelet activation cellular biosynthetic process organic substance metabolic process signal transduction involved in regulation of gene expression organic substance biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to nitrogen compound cellular response to ATP response to organic substance response to organonitrogen compound response to endogenous stimulus response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to organic cyclic compound inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration cellular homeostasis neuron cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of inositol phosphate biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of inositol trisphosphate biosynthetic process regulation of small molecule metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process polyol biosynthetic process small molecule metabolic process phosphorus metabolic process polyol metabolic process regulation of alcohol biosynthetic process positive regulation of phosphorus metabolic process carbohydrate biosynthetic process primary metabolic process positive regulation of inositol phosphate biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process regulation of phosphorus metabolic process positive regulation of carbohydrate metabolic process organic hydroxy compound metabolic process regulation of inositol trisphosphate biosynthetic process alcohol metabolic process positive regulation of cellular metabolic process inositol phosphate metabolic process positive regulation of biosynthetic process inositol trisphosphate metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process small molecule biosynthetic process inositol trisphosphate biosynthetic process organophosphate metabolic process organic hydroxy compound biosynthetic process alcohol biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of cellular biosynthetic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process regulated exocytosis modulation of chemical synaptic transmission synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport vesicle-mediated transport in synapse regulation of regulated secretory pathway synaptic signaling establishment of localization in cell trans-synaptic signaling neurotransmitter secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis neurotransmitter transport regulation of vesicle-mediated transport chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling exocytosis regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis regulation of monoatomic ion transport positive regulation of monoatomic ion transport positive regulation of cytosolic calcium ion concentration positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade eating behavior feeding behavior developmental process regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of anatomical structure morphogenesis cellular response to purine-containing compound response to mechanical stimulus response to abiotic stimulus response to external stimulus response to growth factor adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular developmental process glial cell migration nervous system development neurogenesis multicellular organism development gliogenesis cell differentiation cell migration cell motility system development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein phosphorylation protein modification process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorylation regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance blood circulation regulation of anatomical structure size monoamine transport nitrogen compound transport negative regulation of amine transport regulation of catecholamine secretion negative regulation of biological process negative regulation of transport organic hydroxy compound transport negative regulation of secretion catecholamine transport negative regulation of cellular process negative regulation of norepinephrine secretion negative regulation of secretion by cell norepinephrine transport organic substance transport negative regulation of catecholamine secretion organic cation transport catecholamine secretion amine transport norepinephrine secretion regulation of amine transport regulation of norepinephrine secretion muscle system process relaxation of muscle	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane basal part of cell basal plasma membrane basolateral plasma membrane somatodendritic compartment cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane basal part of cell basal plasma membrane basolateral plasma membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse cell body membrane-bounded organelle organelle cilium apical part of cell apical plasma membrane cell surface presynaptic active zone membrane presynaptic membrane presynapse presynaptic active zone postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR018527	Rubredoxin, iron-binding site	Binding Site
A, B [auth C]	IPR024922	Rubredoxin	Family
A, B [auth C]	IPR024934	Rubredoxin-like domain	Domain
A, B [auth C]	IPR024935	Rubredoxin domain	Domain
A, B [auth C]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A, B [auth C]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A, B [auth C]	IPR000142	P2Y purinoceptor 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C]	Pharos: P47900	Thrombus atypical teratoid rhabdoid tumor large cell medulloblastoma malignant ependymoma myopathy ovarian cancer rheumatoid arthritis tuberculosis glioblastoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma spina bifida thrombotic disease Thrombus atypical teratoid rhabdoid tumor large cell medulloblastoma malignant ependymoma myopathy ovarian cancer rheumatoid arthritis tuberculosis glioblastoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma spina bifida thrombotic disease ulcerative colitis interstitial cystitis malignant colon neoplasm medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth C]	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth C]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth C]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	P2Y₁ receptor in complex with BPTU

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.