4XH9
CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d4xh9b_ | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | G proteins | RhoA | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D [auth E] | d4xh9e_ | Alpha and beta proteins (a/b) | P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | G proteins | RhoA | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | DBL homology domain (DH-domain) | 8084999 | 3000793 | SCOP2B (2022-06-29) |
C [auth D] | SCOP2B Superfamily | DBL homology domain (DH-domain) | 8084999 | 3000793 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Ras-like P-loop GTPases | 8057414 | 3002022 | SCOP2B (2022-06-29) |
D [auth E] | SCOP2B Superfamily | Ras-like P-loop GTPases | 8057414 | 3002022 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF22697 | e4xh9A2 | A: beta barrels | X: PH domain-like | H: PH domain-like (From Topology) | T: PH domain-like | F: PF22697 | ECOD (1.6) |
A | PF00621 | e4xh9A1 | A: alpha bundles | X: DH domain-like | H: DBL homology domain (DH-domain) (From Topology) | T: DBL homology domain (DH-domain) | F: PF00621 | ECOD (1.6) |
C [auth D] | PF22697 | e4xh9D1 | A: beta barrels | X: PH domain-like | H: PH domain-like (From Topology) | T: PH domain-like | F: PF22697 | ECOD (1.6) |
C [auth D] | PF00621 | e4xh9D2 | A: alpha bundles | X: DH domain-like | H: DBL homology domain (DH-domain) (From Topology) | T: DBL homology domain (DH-domain) | F: PF00621 | ECOD (1.6) |
B | PF00071 | e4xh9B1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00071 | ECOD (1.6) |
D [auth E] | PF00071 | e4xh9E1 | A: a/b three-layered sandwiches | X: P-loop domains-like | H: P-loop domains-related | T: P-loop containing nucleoside triphosphate hydrolases | F: PF00071 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
D [auth E] | 3.40.50.300 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, C [auth D] | PF00169 | PH domain (PH) | PH domain | PH stands for pleckstrin homology. | Domain |
A, C [auth D] | PF00621 | RhoGEF domain (RhoGEF) | RhoGEF domain | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains. | Domain |
B, D [auth E] | PF00071 | Ras family (Ras) | Ras family | Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, C [auth D] | IPR001849 | Pleckstrin homology domain | Domain |
A, C [auth D] | IPR037853 | Net1, PH domain | Domain |
A, C [auth D] | IPR000219 | Dbl homology (DH) domain | Domain |
A, C [auth D] | IPR035899 | Dbl homology (DH) domain superfamily | Homologous Superfamily |
A, C [auth D] | IPR011993 | PH-like domain superfamily | Homologous Superfamily |
A, C [auth D] | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Conserved Site |
B, D [auth E] | IPR001806 | Small GTPase | Family |
B, D [auth E] | IPR003578 | Small GTPase Rho | Family |
B, D [auth E] | IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily |
B, D [auth E] | IPR005225 | Small GTP-binding protein domain | Domain |