Annotations: 4XD9

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Class II aaRS ABD-related	8092349	3000465	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Class II aaRS ABD-related	8092350	3000465	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Class II aaRS ABD-related	8092350	3000465	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Class II aaRS ABD-related	8092349	3000465	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Rrs1-like	8092360	3002595	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Rrs1-like	8092360	3002595	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04427	e4xd9A1	A: a/b three-layered sandwiches	X: Anticodon-binding domain of Class II aaRS (From Topology)	H: Anticodon-binding domain of Class II aaRS (From Topology)	T: Anticodon-binding domain of Class II aaRS	F: PF04427	ECOD (1.6)
C	PF04427	e4xd9C1	A: a/b three-layered sandwiches	X: Anticodon-binding domain of Class II aaRS (From Topology)	H: Anticodon-binding domain of Class II aaRS (From Topology)	T: Anticodon-binding domain of Class II aaRS	F: PF04427	ECOD (1.6)
B	PF04939	e4xd9B1	A: a+b two layers	X: Rrs1 (From Topology)	H: Rrs1 (From Topology)	T: Rrs1	F: PF04939	ECOD (1.6)
D	PF04939	e4xd9D1	A: a+b two layers	X: Rrs1 (From Topology)	H: Rrs1 (From Topology)	T: Rrs1	F: PF04939	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF04427	Brix domain (Brix)	Brix domain	-	Domain
B, D	PF04939	Ribosome biogenesis regulatory protein (RRS1) (RRS1)	Ribosome biogenesis regulatory protein (RRS1)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Ribosome biogenesis protein, putative (AFU_orthologue AFUA_8G04790)	RNA binding binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding rRNA binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression ribosomal large subunit biogenesis macromolecule biosynthetic process nucleic acid metabolic process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) organic cyclic compound metabolic process biosynthetic process nucleic acid catabolic process cellular process metabolic process macromolecule metabolic process maturation of LSU-rRNA organelle assembly non-membrane-bounded organelle assembly cellular component organization organelle organization cellular component assembly ribosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle preribosome protein-containing complex ribonucleoprotein complex preribosome, large subunit precursor
B, D	Ribosome biogenesis protein (Rrs1), putative (AFU_orthologue AFUA_7G04430)	RNA binding binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding	cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular process cellular component organization or biogenesis ribosomal large subunit biogenesis cellular biosynthetic process RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleobase-containing compound metabolic process organic substance metabolic process maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular process cellular component organization or biogenesis ribosomal large subunit biogenesis cellular biosynthetic process RNA metabolic process rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleobase-containing compound metabolic process organic substance metabolic process maturation of SSU-rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) organic substance biosynthetic process RNA processing rRNA metabolic process endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process ribosomal small subunit biogenesis nucleic acid metabolic process organic cyclic compound metabolic process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biosynthetic process nucleic acid catabolic process metabolic process macromolecule metabolic process organelle assembly non-membrane-bounded organelle assembly cellular component organization organelle organization cellular component assembly ribosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle preribosome protein-containing complex ribonucleoprotein complex preribosome, large subunit precursor

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR039770	Ribosome biogenesis protein Rpf2	Family
A, C	IPR007109	Brix domain	Domain
B, D	IPR007023	Ribosomal biogenesis regulatory protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.