4X91

Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02450	e4x91A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)
B	PF02450	e4x91B1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)
C	PF02450	e4x91C1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)
D	PF02450	e4x91D1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF02450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02450	Lecithin:cholesterol acyltransferase (LCAT)	Lecithin:cholesterol acyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Group XV phospholipase A2	hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity phosphatidylserine 1-acylhydrolase activity catalytic activity phospholipase activity lipase activity binding phospholipid binding lipid binding 1-acyl-2-lysophosphatidylserine acylhydrolase activity lysophospholipase activity phosphatidyl phospholipase B activity O-acyltransferase activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity phosphatidylserine 1-acylhydrolase activity catalytic activity phospholipase activity lipase activity binding phospholipid binding lipid binding 1-acyl-2-lysophosphatidylserine acylhydrolase activity lysophospholipase activity phosphatidyl phospholipase B activity O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acylglycerol O-acyltransferase activity phospholipase A2 activity calcium-independent phospholipase A2 activity phospholipase A1 activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process catabolic process phospholipid catabolic process glycerophospholipid metabolic process cellular metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process catabolic process phospholipid catabolic process glycerophospholipid metabolic process glycerolipid catabolic process organophosphate catabolic process cellular lipid catabolic process cellular catabolic process phosphatidylcholine metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process lipid catabolic process phosphatidylcholine catabolic process glycerolipid metabolic process glycerophospholipid catabolic process organic substance catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process fatty acid metabolic process carboxylic acid metabolic process fatty acid catabolic process monocarboxylic acid metabolic process small molecule catabolic process phosphatidylglycerol metabolic process phosphatidylethanolamine catabolic process phosphatidylethanolamine metabolic process phosphatidylserine metabolic process cellular modified amino acid metabolic process neutral lipid metabolic process diacylglycerol biosynthetic process neutral lipid biosynthetic process cellular biosynthetic process lipid biosynthetic process acylglycerol biosynthetic process diacylglycerol metabolic process biosynthetic process glycerolipid biosynthetic process organic substance biosynthetic process acylglycerol metabolic process ceramide metabolic process membrane lipid metabolic process sphingolipid metabolic process amide metabolic process	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen lytic vacuole vacuole cytoplasm lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003386	Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase	Family
A, B, C, D	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q8NCC3	diabetes mellitus medulloblastoma large cell medulloblastoma ovarian cancer malignant ependymoma tuberculosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.