4WZ8

Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d4wz8b1	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Biotin dependent carboxylase carboxyltransferase domain	automated matches	Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ],	SCOPe (2.08)
B [auth C]	d4wz8c1	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Biotin dependent carboxylase carboxyltransferase domain	automated matches	Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	ClpP/crotonase	8035307	3000033	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	ClpP/crotonase	8035309	3000033	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	ClpP/crotonase	8035309	3000033	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	ClpP/crotonase	8035307	3000033	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Carboxyl_trans_C	e4wz8B1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Carboxyl_trans_C	ECOD (1.6)
B [auth C]	Carboxyl_trans_C	e4wz8C1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Carboxyl_trans_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
A [auth B]	2.40.460.10	Mainly Beta	Beta Barrel	ClpP/crotonase fold	Biotin dependent carboxylase carboxyltransferase	CATH (4.3.0)
B [auth C]	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
B [auth C]	2.40.460.10	Mainly Beta	Beta Barrel	ClpP/crotonase fold	Biotin dependent carboxylase carboxyltransferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth C]	PF01039	Carboxyl transferase domain (Carboxyl_trans)	Carboxyl transferase domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth C]	Acetyl-CoA carboxylase	biotin carboxylase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding biotin carboxylase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds identical protein binding protein binding protein homodimerization activity protein dimerization activity amide binding acyl-CoA binding acetyl-CoA binding sulfur compound binding carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity cation binding metal ion binding	nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process malonyl-CoA metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process sulfur compound metabolic process nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process malonyl-CoA metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process sulfur compound metabolic process thioester metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process amide biosynthetic process nucleotide metabolic process organic cyclic compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process thioester biosynthetic process cellular biosynthetic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process purine nucleoside bisphosphate biosynthetic process amide metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process nucleoside bisphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organophosphate metabolic process cellular process protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport acetyl-CoA metabolic process acetyl-CoA biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process cellular lipid metabolic process monocarboxylic acid metabolic process lipid metabolic process long-chain fatty acid biosynthetic process long-chain fatty acid metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane acetyl-CoA carboxylase complex protein-containing complex catalytic complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth C]	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal	Domain
A [auth B], B [auth C]	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A [auth B], B [auth C]	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal	Domain
A [auth B], B [auth C]	IPR049074	Acetyl-CoA carboxylase, BT domain	Domain
A [auth B], B [auth C]	IPR011764	Biotin carboxylation domain	Domain
A [auth B], B [auth C]	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	Domain
A [auth B], B [auth C]	IPR049076	Acetyl-CoA carboxylase	Family
A [auth B], B [auth C]	IPR011054	Rudiment single hybrid motif	Homologous Superfamily
A [auth B], B [auth C]	IPR013537	Acetyl-CoA carboxylase, central domain	Domain
A [auth B], B [auth C]	IPR011053	Single hybrid motif	Homologous Superfamily
A [auth B], B [auth C]	IPR001882	Biotin-binding site	Binding Site
A [auth B], B [auth C]	IPR000089	Biotin/lipoyl attachment	Domain
A [auth B], B [auth C]	IPR005481	Biotin carboxylase-like, N-terminal domain	Domain
A [auth B], B [auth C]	IPR011761	ATP-grasp fold	Domain
A [auth B], B [auth C]	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
A [auth B], B [auth C]	IPR005482	Biotin carboxylase, C-terminal	Domain
A [auth B], B [auth C]	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	Domain
A [auth B], B [auth C]	IPR016185	Pre-ATP-grasp domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.