4WYU

Crystal Structure of Scribble PDZ34 tandem in complex with its target peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e4wyuA2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
C [auth B]	PF00595	e4wyuB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C [auth B]	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Protein scribble homolog	cell adhesion molecule binding cadherin binding protein binding binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development animal organ morphogenesis system development developmental process embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis cellular process inner ear receptor cell stereocilium organization glial cell migration gliogenesis astrocyte cell migration cell migration cell motility cell population proliferation regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process positive chemotaxis chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion tube development mammary gland morphogenesis mammary gland development gland development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis tube morphogenesis gland morphogenesis mammary gland epithelium development epithelial tube morphogenesis post-anal tail morphogenesis embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation primary neural tube formation embryo development ending in birth or egg hatching morphogenesis of embryonic epithelium neural tube development neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport neurotransmitter receptor transport postsynaptic membrane to endosome protein localization to endosome vesicle-mediated transport localization cellular macromolecule localization neurotransmitter receptor transport organic substance transport protein localization to early endosome establishment of localization protein-containing complex localization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse receptor clustering localization within membrane protein localization to membrane apoptotic process involved in development apoptotic process involved in morphogenesis import into cell regulation of localization regulation of cellular component organization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of biological quality regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis cochlear nucleus development pons development head development brain development central nervous system development metencephalon development hindbrain development neural nucleus development synaptic vesicle endocytosis synaptic vesicle cycle presynaptic endocytosis synaptic vesicle recycling negative regulation of lymphocyte proliferation regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of activated T cell proliferation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation polarized epithelial cell differentiation morphogenesis of a polarized epithelium regulation of signaling signaling regulation of receptor recycling regulation of macromolecule metabolic process receptor recycling positive regulation of metabolic process organic substance metabolic process receptor metabolic process positive regulation of receptor recycling positive regulation of macromolecule metabolic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of signaling wound healing response to stress response to wounding establishment of cell polarity establishment or maintenance of bipolar cell polarity establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity establishment of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity activation of GTPase activity positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity protein localization to adherens junction protein localization to cell-cell junction establishment of lymphocyte polarity establishment of T cell polarity establishment of organelle localization regulated exocytosis synaptic vesicle targeting synaptic vesicle exocytosis vesicle targeting cell communication synaptic signaling secretion by cell organelle localization signal release vesicle localization trans-synaptic signaling neurotransmitter secretion secretion establishment of vesicle localization export from cell cell-cell signaling neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling exocytic process neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to plasma membrane establishment of protein localization to postsynaptic membrane endocytic recycling neurotransmitter receptor transport to plasma membrane neurotransmitter receptor transport, endosome to plasma membrane neurotransmitter receptor transport, endosome to postsynaptic membrane protein localization to cell periphery protein localization to postsynaptic membrane establishment of protein localization to membrane protein localization to plasma membrane intracellular transport endosomal transport vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport intracellular protein transport regulation of type II interferon production type II interferon production cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process positive regulation of type II interferon production regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process establishment or maintenance of epithelial cell apical/basal polarity negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic cell cycle regulation of mitotic cell cycle cell cycle regulation of cell cycle	extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane cellular anatomical entity synaptic membrane extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane cellular anatomical entity synaptic membrane extrinsic component of synaptic membrane postsynapse postsynaptic density neuron to neuron synapse organelle postsynaptic membrane plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell-cell junction anchoring junction myelin sheath abaxonal region myelin sheath extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle basal part of cell basal plasma membrane basolateral plasma membrane Scrib-APC-beta-catenin complex protein-containing complex intracellular anatomical structure cytoplasm glutamatergic synapse adherens junction presynapse cell-cell contact zone nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen immunological synapse
B [auth D], D [auth C]	peptide SER-TRP-PHE-GLN-THR-ASP-LEU	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR001611	Leucine-rich repeat	Repeat
A, C [auth B]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, C [auth B]	IPR036034	PDZ superfamily	Homologous Superfamily
A, C [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, C [auth B]	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: Q14160	neural tube defects, susceptibility to astrocytic tumor lung cancer ovarian cancer spina bifida intellectual disability malignant ependymoma pancreatic ductal adenocarcinoma tuberculosis lung adenocarcinoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.